C
Chadwick T. Davis
Researcher at University of Utah
Publications - 14
Citations - 1101
Chadwick T. Davis is an academic researcher from University of Utah. The author has contributed to research in topics: Vascular permeability & Proinflammatory cytokine. The author has an hindex of 9, co-authored 12 publications receiving 753 citations. Previous affiliations of Chadwick T. Davis include Boise State University.
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Journal ArticleDOI
Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes
Mark-Anthony Bray,Shantanu Singh,Han Han,Chadwick T. Davis,Blake Borgeson,Cathy L Hartland,Maria Kost-Alimova,Sigrun M. Gustafsdottir,Christopher C. Gibson,Anne E. Carpenter +9 more
TL;DR: This protocol describes the design and execution of experiments using Cell Painting, which is a morphological profiling assay that multiplexes six fluorescent dyes, imaged in five channels, to reveal eight broadly relevant cellular components or organelles.
Journal ArticleDOI
Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability
Weiquan Zhu,Nyall London,Christopher C. Gibson,Chadwick T. Davis,Zongzhong Tong,Lise K. Sorensen,Dallas Shi,Jinping Guo,Jinping Guo,Matthew C. P. Smith,Allie H. Grossmann,Kirk R. Thomas,Dean Y. Li +12 more
TL;DR: The direct, immediate and disruptive effects of IL-1β on endothelial stability in a human in vitro cell model are NF-κB independent and are instead the result of signalling through the small GTPase ADP-ribosylation factor 6 (ARF6) and its activator ARF nucleotide binding site opener (ARNO).
Journal ArticleDOI
Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation.
Christopher C. Gibson,Weiquan Zhu,Chadwick T. Davis,Jay A. Bowman-Kirigin,Aubrey C. Chan,Jing Ling,Ashley E. Walker,Luca Goitre,Simona Delle Monache,Saverio Francesco Retta,Yan-Ting Shiu,Allie H. Grossmann,Kirk R. Thomas,Anthony J. Donato,Lisa A. Lesniewski,Kevin J. Whitehead,Dean Y. Li +16 more
TL;DR: It is suggested that the structure-function screening platform presented here may be adapted and scaled to facilitate drug discovery for diverse loss-of-function genetic vascular disease.
Posted ContentDOI
Identification of potential treatments for COVID-19 through artificial intelligence-enabled phenomic analysis of human cells infected with SARS-CoV-2
Katie Heiser,Peter F. McLean,Chadwick T. Davis,Ben Fogelson,Hannah B. Gordon,Pamela Jacobson,Brett L. Hurst,Ben J. Miller,Ronald W. Alfa,Berton A. Earnshaw,Mason L. Victors,Yolanda T. Chong,Imran S. Haque,Adeline S. Low,Christopher C. Gibson +14 more
TL;DR: In this assay, remdesivir is the only antiviral tested with strong efficacy, neither chloroquine nor hydroxychloroquine have any beneficial effect in this human cell model, and a small number of compounds not currently being pursued clinically for SARS-CoV-2 have efficacy.
Journal ArticleDOI
Crohn’s Disease and Genetic Hitchhiking at IBD5
Chad D. Huff,David J. Witherspoon,Yuhua Zhang,Chandler Gatenbee,Lee A. Denson,Subra Kugathasan,Hakon Hakonarson,April Whiting,Chadwick T. Davis,Wilfred Wu,Jinchuan Xing,W. Scott Watkins,Michael J. Bamshad,Jonathan P. Bradfield,Kazima B. Bulayeva,Tatum S. Simonson,Lynn B. Jorde,Stephen L. Guthery +17 more
TL;DR: Association results and expression data support IRF1 as a strong candidate for Crohn's disease causation and the hypothesis of disease-variant hitchhiking.