C
Chad D. Huff
Researcher at University of Texas MD Anderson Cancer Center
Publications - 111
Citations - 8954
Chad D. Huff is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Population & Biology. The author has an hindex of 35, co-authored 90 publications receiving 7757 citations. Previous affiliations of Chad D. Huff include University of Texas Health Science Center at Houston & University of Utah.
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Journal ArticleDOI
Exome sequencing identifies the cause of a Mendelian disorder
Sarah B H Ng,Kati J. Buckingham,Choli Lee,Abigail W. Bigham,Holly K. Tabor,Holly K. Tabor,Karin M. Dent,Chad D. Huff,Paul Shannon,Ethylin Wang Jabs,Ethylin Wang Jabs,Deborah A. Nickerson,Jay Shendure,Michael J. Bamshad,Michael J. Bamshad +14 more
TL;DR: Exome sequencing of a small number of unrelated affected individuals is a powerful, efficient strategy for identifying the genes underlying rare mendelian disorders and will likely transform the genetic analysis of monogenic traits.
Journal ArticleDOI
Analysis of genetic inheritance in a family quartet by whole-genome sequencing
Jared C. Roach,Gustavo Glusman,Arian F.A. Smit,Chad D. Huff,Chad D. Huff,Robert Hubley,Paul Shannon,Lee Rowen,Krishna Pant,Nathan Goodman,Michael J. Bamshad,Jay Shendure,Radoje Drmanac,Lynn B. Jorde,Leroy Hood,David J. Galas +15 more
TL;DR: Family-based genome analysis enabled us to narrow the candidate genes for both of these Mendelian disorders to only four and demonstrate the value of complete genome sequencing in families.
Journal ArticleDOI
Genetic Evidence for High-Altitude Adaptation in Tibet
Tatum S. Simonson,Yingzhong Yang,Chad D. Huff,Haixia Yun,Ga Qin,David J. Witherspoon,Zhen-Zhong Bai,Felipe R. Lorenzo,Jinchuan Xing,Lynn B. Jorde,Josef T. Prchal,Ri Li Ge +11 more
TL;DR: Identifying genes under selection in humans living at high altitudes provides support for previously hypothesized mechanisms of high-altitude adaptation and illuminates the complexity of hypoxia-response pathways in humans.
Journal ArticleDOI
De novo mutations in ATP1A3 cause alternating hemiplegia of childhood
Erin L. Heinzen,Kathryn J. Swoboda,Yuki Hitomi,Fiorella Gurrieri,Sophie Nicole,Sophie Nicole,Sophie Nicole,Boukje de Vries,F Danilo Tiziano,Bertrand Fontaine,Bertrand Fontaine,Bertrand Fontaine,Nicole M. Walley,Sinéad Heavin,Eleni Panagiotakaki,Stefania Fiori,Emanuela Abiusi,Lorena Di Pietro,Matthew T. Sweney,Tara M. Newcomb,Louis Viollet,Chad D. Huff,Lynn B. Jorde,Sandra P. Reyna,Kelley J. Murphy,Kevin V. Shianna,Curtis Gumbs,Latasha Little,Kenneth Silver,Louis J. Ptáček,Joost Haan,Michel D. Ferrari,Ann M. E. Bye,Geoffrey K. Herkes,Charlotte M Whitelaw,David Webb,Bryan Lynch,Peter Uldall,Mary D King,Ingrid E. Scheffer,Ingrid E. Scheffer,Giovanni Neri,Alexis Arzimanoglou,Alexis Arzimanoglou,Alexis Arzimanoglou,Arn M. J. M. van den Maagdenberg,Sanjay M. Sisodiya,Mohamad A. Mikati,David Goldstein +48 more
TL;DR: De novo ATP1A3 mutations are identified as the primary cause ofAlternating hemiplegia of childhood and insight into disease pathophysiology is offered by expanding the spectrum of phenotypes associated with mutations in ATP 1A3.
Journal ArticleDOI
A Comprehensive Map of Mobile Element Insertion Polymorphisms in Humans
Chip Stewart,Deniz Kural,Michael Strömberg,Jerilyn A. Walker,Miriam K. Konkel,Adrian M. Stütz,Alexander E. Urban,Fabian Grubert,Hugo Y. K. Lam,Wan-Ping Lee,Michele Busby,Amit Indap,Erik Garrison,Chad D. Huff,Jinchuan Xing,Michael Snyder,Lynn B. Jorde,Mark A. Batzer,Jan O. Korbel,Gabor T. Marth +19 more
TL;DR: A direct comparison of MEI and SNP diversity levels suggests a differential mobile element insertion rate among populations, and a comprehensive map of 7,380 MEI polymorphisms from the 1000 Genomes Project whole-genome sequencing data is presented.