W
Weiquan Zhu
Researcher at University of Utah
Publications - 29
Citations - 1930
Weiquan Zhu is an academic researcher from University of Utah. The author has contributed to research in topics: Endothelial stem cell & Vascular permeability. The author has an hindex of 17, co-authored 28 publications receiving 1709 citations. Previous affiliations of Weiquan Zhu include Peking Union Medical College.
Papers
More filters
Journal ArticleDOI
Hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells.
TL;DR: It is demonstrated, using rat mesenchymal stem cells (MSCs), that cells undergo caspase‐dependent apoptosis in response to hypoxia and serum deprivation, which are both components of ischemia in vivo.
Journal ArticleDOI
Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza
Nyall London,Weiquan Zhu,Fernando A. Bozza,Matthew C. P. Smith,Daniel Greif,Lise K. Sorensen,Luming Chen,Yuuki Kaminoh,Aubrey C. Chan,Samuel F. Passi,Craig W. Day,Dale L. Barnard,Guy A. Zimmerman,Mark A. Krasnow,Dean Y. Li +14 more
TL;DR: In this article, the Robo4-dependent signaling pathway was used to strengthen the vascular barrier, diminishing deleterious aspects of the host's response to the pathogen-induced cytokine storm.
Journal ArticleDOI
Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity
Christopher A. Jones,Naoyuki Nishiya,Naoyuki Nishiya,Nyall London,Weiquan Zhu,Lise K. Sorensen,Aubrey C. Chan,Chinten James Lim,Haoyu Chen,Haoyu Chen,Qisheng Zhang,Peter G. Schultz,Alaa M. Hayallah,Alaa M. Hayallah,Kirk R. Thomas,Michael Famulok,Kang Zhang,Kang Zhang,Mark H. Ginsberg,Dean Y. Li +19 more
TL;DR: It is demonstrated that Robo4 mediates Slit2-dependent suppression of cellular protrusive activity through direct interaction with the intracellular adaptor protein paxillin and its paralogue, Hic-5, which identifies a new therapeutic target for ameliorating diseases involving the vascular system.
Journal ArticleDOI
Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability
Weiquan Zhu,Nyall London,Christopher C. Gibson,Chadwick T. Davis,Zongzhong Tong,Lise K. Sorensen,Dallas Shi,Jinping Guo,Jinping Guo,Matthew C. P. Smith,Allie H. Grossmann,Kirk R. Thomas,Dean Y. Li +12 more
TL;DR: The direct, immediate and disruptive effects of IL-1β on endothelial stability in a human in vitro cell model are NF-κB independent and are instead the result of signalling through the small GTPase ADP-ribosylation factor 6 (ARF6) and its activator ARF nucleotide binding site opener (ARNO).
Journal ArticleDOI
Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation.
Christopher C. Gibson,Weiquan Zhu,Chadwick T. Davis,Jay A. Bowman-Kirigin,Aubrey C. Chan,Jing Ling,Ashley E. Walker,Luca Goitre,Simona Delle Monache,Saverio Francesco Retta,Yan-Ting Shiu,Allie H. Grossmann,Kirk R. Thomas,Anthony J. Donato,Lisa A. Lesniewski,Kevin J. Whitehead,Dean Y. Li +16 more
TL;DR: It is suggested that the structure-function screening platform presented here may be adapted and scaled to facilitate drug discovery for diverse loss-of-function genetic vascular disease.