K
Ki-Sun Park
Researcher at National Institutes of Health
Publications - 9
Citations - 301
Ki-Sun Park is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Genomic imprinting & Phosphorylation. The author has an hindex of 5, co-authored 8 publications receiving 233 citations. Previous affiliations of Ki-Sun Park include New Generation University College & Seoul National University.
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Journal ArticleDOI
MIR144* inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2
Jin Kyung Kim,Hye-Mi Lee,Ki-Sun Park,Dong-Min Shin,Tae Sung Kim,Yi Sak Kim,Hyun-Woo Suh,Soo Yeon Kim,In Soo Kim,Jin-Man Kim,Ji-Woong Son,Kyung Mok Sohn,Sung Soo Jung,Chaeuk Chung,Sang-Bae Han,Chul-Su Yang,Eun-Kyeong Jo +16 more
TL;DR: This study shows that Mtb significantly induces the expression of MIR144*/hsa-miR-144-5p, which targets the 3′-untranslated region of DRAM2 (DNA damage regulated autophagy modulator 2) in human monocytes and macrophages, and reveals that DR AM2 is a key coordinator of autophagic activation that enhances antimicrobial activity against Mtb.
Journal ArticleDOI
Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation.
Jae-Min Yuk,Tae Sung Kim,Soo Yeon Kim,Hye-Mi Lee,Jeongsu Han,Catherine R. Dufour,Jin Kyung Kim,Hyo Sun Jin,Chul-Su Yang,Ki-Sun Park,Chul-Ho Lee,Jin-Man Kim,Gi Ryang Kweon,Hueng-Sik Choi,Jean-Marc Vanacker,David D. Moore,Vincent Giguère,Eun-Kyeong Jo +17 more
TL;DR: It is demonstrated that ERRα negatively regulates Toll-like receptor (TLR)-induced inflammation by promoting Tnfaip3 transcription and fine-tuning of metabolic reprogramming in macrophages, unraveling a previously unappreciated role for ERR α as a negative regulator of TLR-induced inflammatory responses.
Journal ArticleDOI
Circular RNAs and competing endogenous RNA (ceRNA) networks.
TL;DR: In recent years, advances in bioinformatics approaches have allowed a systematic characterization of circular RNAs across a variety of cell types, and investigators have begun focusing on the possibility that circRNAs operate as part of competing endogenous RNA (ceRNA) regulatory networks.
Journal ArticleDOI
Loss of imprinting mutations define both distinct and overlapping roles for misexpression of IGF2 and of H19 lncRNA.
TL;DR: New biochemical roles for the H19 lncRNA are identified and it is underscored that LOI phenotypes are multigenic so that complex interactions will contribute to disease outcomes.
Posted ContentDOI
Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries
Jason Flannick,Josep M. Mercader,Christian Fuchsberger,Miriam S. Udler,Anubha Mahajan,Jennifer Wessel,Tanya M. Teslovich,Lizz Caulkins,Ryan Koesterer,Thomas W. Blackwell,Eric Boerwinkle,Eric Boerwinkle,Jennifer A. Brody,Lin Chen,Song Chen,Cecilia Contreras-Cubas,Emilio J. Cordova,Adolfo Correa,Maria L. Cortes,Ralph A. DeFronzo,Lawrence M. Dolan,Kimberly L. Drews,Amanda F. Elliott,Amanda F. Elliott,James S. Floyd,S. Gabriel,Garay-Sevilla Me,Humberto García-Ortiz,Myron D. Gross,Sohee Han,Hanks S,Nancy L. Heard-Costa,Anne U. Jackson,Marit E. Jørgensen,Marit E. Jørgensen,Marit E. Jørgensen,Hyun Min Kang,Kelsey M,Bong-Jo Kim,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Johanna Kuusisto,Joseph B. Leader,Allan Linneberg,Allan Linneberg,Ching-Ti Liu,Jianjun Liu,Jianjun Liu,Lyssenko,Lyssenko,Alisa K. Manning,Anthony Marcketta,Malacara-Hernandez Jm,Angélica Martínez-Hernández,Matsuo K,Elizabeth J. Mayer-Davis,Elvia Mendoza-Caamal,Karen L. Mohlke,Alanna C. Morrison,Anne Ndungu,Maggie C.Y. Ng,Colm O'Dushlaine,Anthony Payne,Catherine Pihoker,Wendy S. Post,Michael Preuss,Bruce M. Psaty,Bruce M. Psaty,Ramachandran S. Vasan,Rayner Nw,Alexander P. Reiner,Cristina Revilla-Monsalve,Neil R. Robertson,Nicola Santoro,Claudia Schurmann,Wing-Yee So,Heather M. Stringham,T. M. Strom,Claudia Ht Tam,Farook Thameem,Brian Tomlinson,Jason M. Torres,Russel Tracy,van Dam Rm,Marijana Vujkovic,Shuai Wang,Ryan P. Welch,Daniel R. Witte,Tien Yin Wong,Gil Atzmon,Gil Atzmon,Nir Barzilai,John Blangero,Lori L. Bonnycastle,Donald W. Bowden,John C. Chambers,John C. Chambers,John C. Chambers,Edmund Chan,Ching-Yu Cheng,Shin Yc,Francis S. Collins,de Vries Ps,Ravindranath Duggirala,Benjamin Glaser,Clicerio Gonzalez,Ma Elena Gonzalez,Leif Groop,Leif Groop,Jaspal S. Kooner,Soo Heon Kwak,Markku Laakso,Donna M. Lehman,Peter M. Nilsson,Tim D. Spector,Tai Es,Tiinamaija Tuomi,J. Tuomilehto,James G. Wilson,Carlos A. Aguilar-Salinas,Erwin P. Bottinger,Brian Burke,David J. Carey,Juliana C.N. Chan,Josée Dupuis,Philippe M. Frossard,Heckbert,Mi Yeong Hwang,Young-Jin Kim,Kirchner Hl,Lee J,Loos R,Ronald C.W. Ma,Morris Ad,C.J. O'Donnell,Colin N. A. Palmer,James S. Pankow,Ki-Sun Park,Ki-Sun Park,Ki-Sun Park,Asif Rasheed,Danish Saleheen,Xueling Sim,Kerrin S. Small,Yik Ying Teo,Christopher A. Haiman,Craig L. Hanis,Brian E. Henderson,Lorena Orozco,Teresa Tusié-Luna,Frederick E. Dewey,Aris Baras,Christian Gieger,Thomas Meitinger,Konstantin Strauch,Leslie A. Lange,Niels Grarup,Torben Hansen,Torben Hansen,Oluf Pedersen,Zeitler P,Dana Dabelea,Gonçalo R. Abecasis,Graeme I. Bell,Nancy J. Cox,Mark Seielstad,Mark Seielstad,Robert Sladek,James B. Meigs,James B. Meigs,S. S. Rich,Jerome I. Rotter,David Altshuler,Noël P. Burtt,Laura J. Scott,Andrew P. Morris,Jose C. Florez,Mark I. McCarthy,Boehnke M +179 more
TL;DR: An exome sequence analysis of type 2 diabetes cases and controls presents a Bayesian framework to recalibrate association p-values as posterior probabilities of association, estimating that reaching p<0.05 in this study increases the odds of causal T2D association for a nonsynonymous variant by a factor of 1.3.