Kyung Mok Sohn

TL;DR: Comparative and kinetic analyses revealed that high viral loads, weak antibody responses, and lymphopenia accompanying thrombocytopenia were associated with disease mortality, whereas persistent and gradual increases in lymphocyte responses might be required for effective immunity against MERS-CoV infection.

TL;DR: It is reported here that toll-like receptor (TLR) 4-mediated inflammatory signaling molecules are upregulated in peripheral blood mononuclear cells from COVID-19 patients, compared with healthy controls (HC).

TL;DR: The clinical features of MERS-CoV infection in the Republic of Korea were similar to those of previous outbreaks in the Middle East, however, the overall mortality rate was lower than that in previous reports.

TL;DR: This study shows that Mtb significantly induces the expression of MIR144*/hsa-miR-144-5p, which targets the 3′-untranslated region of DRAM2 (DNA damage regulated autophagy modulator 2) in human monocytes and macrophages, and reveals that DR AM2 is a key coordinator of autophagic activation that enhances antimicrobial activity against Mtb.

TL;DR: In this paper, the authors evaluated clinical outcomes and risk factors related to de-escalation therapy in patients with intensive care unit (ICU)-acquired pneumonia, and showed that patients in the deescalation group showed a significantly lower pneumonia-related mortality rate compared to patients in a non-de-decision group.