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Xiaoyu Du
Researcher at Tsinghua University
Publications - 7
Citations - 3404
Xiaoyu Du is an academic researcher from Tsinghua University. The author has contributed to research in topics: Carmofur & Drug repositioning. The author has an hindex of 6, co-authored 6 publications receiving 1947 citations. Previous affiliations of Xiaoyu Du include ShanghaiTech University.
Papers
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Journal ArticleDOI
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
Zhenming Jin,Zhenming Jin,Xiaoyu Du,Yechun Xu,Yong-Qiang Deng,Meiqin Liu,Yao Zhao,Bing Zhang,Xiaofeng Li,Leike Zhang,Chao Peng,Yinkai Duan,Jing Yu,Lin Wang,Kailin Yang,Fengjiang Liu,Ren-Di Jiang,Xing-Lou Yang,Tian You,Liu X,Xiuna Yang,Fang Bai,Hong Liu,Xiang Liu,Luke W. Guddat,Wenqing Xu,Wenqing Xu,Gengfu Xiao,Cheng-Feng Qin,Zhengli Shi,Hualiang Jiang,Hualiang Jiang,Zihe Rao,Zihe Rao,Zihe Rao,Haitao Yang +35 more
TL;DR: A programme of structure-assisted drug design and high-throughput screening identifies six compounds that inhibit the main protease of SARS-CoV-2, demonstrating the ability of this strategy to isolate drug leads with clinical potential.
Journal ArticleDOI
Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur.
Zhenming Jin,Zhenming Jin,Yao Zhao,Yuan Sun,Bing Zhang,Haofeng Wang,Haofeng Wang,Yan Wu,Yan Zhu,Chen Zhu,Tianyu Hu,Xiaoyu Du,Xiaoyu Du,Yinkai Duan,Jing Yu,Xiaobao Yang,Xiuna Yang,Kailin Yang,Xiang Liu,Luke W. Guddat,Gengfu Xiao,Leike Zhang,Haitao Yang,Zihe Rao,Zihe Rao,Zihe Rao +25 more
TL;DR: The X-ray crystal structure of SARS-CoV-2 with inhibitor carmofur reveals the mechanism of action of this compound and opens the way to develop more potent drugs.
Posted ContentDOI
Structure-based drug design, virtual screening and high-throughput screening rapidly identify antiviral leads targeting COVID-19
Zhenming Jin,Zhenming Jin,Xiaoyu Du,Yechun Xu,Yong-Qiang Deng,Meiqin Liu,Yao Zhao,Bing Zhang,Xiaofeng Li,Leike Zhang,Chao Peng,Yinkai Duan,Jing Yu,Lin Wang,Kailin Yang,Fengjiang Liu,Ren-Di Jiang,Xing-Lou Yang,Tian You,Liu X,Xiuna Yang,Fang Bai,Hong Liu,Xiang Liu,Luke W. Guddat,Wenqing Xu,Wenqing Xu,Gengfu Xiao,Cheng-Feng Qin,Zhengli Shi,Hualiang Jiang,Hualiang Jiang,Zihe Rao,Zihe Rao,Zihe Rao,Haitao Yang +35 more
TL;DR: The results demonstrate the efficacy of this screening strategy, and establishes a new paradigm for the rapid discovery of drug leads with clinical potential in response to new infectious diseases where no specific drugs or vaccines are available.
Journal ArticleDOI
High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors.
Yao Zhao,Xiaoyu Du,Yinkai Duan,Xiaoyan Pan,Yifang Sun,Tian You,Lin Han,Zhenming Jin,Zhenming Jin,Weijuan Shang,Jing Yu,Hangtian Guo,Qianying Liu,Yan Wu,Chao Peng,Jun Wang,Chenghao Zhu,Xiuna Yang,Kailin Yang,Ying Lei,Luke W. Guddat,Wenqing Xu,Wenqing Xu,Gengfu Xiao,Lei Sun,Leike Zhang,Zihe Rao,Zihe Rao,Haitao Yang +28 more
TL;DR: YM155, cryptotanshinone, Tanase I, and GRL0617 were found to have the most potent antiviral activity with an EC50 value of 170 nmol/L.
Journal ArticleDOI
Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2
Yao Zhao,Yan-Bing Zhu,Xiang Liu,Zhe Zhu Jin,Yinkai Duan,Cheng Wu,Lu Feng,Xiaoyu Du,Jinyi Zhao,Maolin Shao,Bing Zhang,Xiuna Yang,Lijie Wu,Xiaoyun Ji,Luke W. Guddat,Kailin Yang,Zihe Rao,Haitao Yang +17 more
TL;DR: This study underscores the mechanistic function of Mpro in the viral life cycle, which provides structural insights to develop effective inhibitors against this essential target of SARS-CoV-2.