S
Stuart M. Haslam
Researcher at Imperial College London
Publications - 221
Citations - 13025
Stuart M. Haslam is an academic researcher from Imperial College London. The author has contributed to research in topics: Glycosylation & Glycan. The author has an hindex of 60, co-authored 210 publications receiving 11445 citations. Previous affiliations of Stuart M. Haslam include Kobe Pharmaceutical University & State University of New York System.
Papers
More filters
Journal ArticleDOI
GlycoWorkbench: a tool for the computer-assisted annotation of mass spectra of glycans
TL;DR: GlycoWorkbench is a software tool developed by the EUROCarbDB initiative to assist the manual interpretation of MS data to evaluate a set of structures proposed by the user by matching the corresponding theoretical list of fragment masses against the list of peaks derived from the spectrum.
Journal ArticleDOI
N-Linked Glycosylation in Campylobacter jejuni and Its Functional Transfer into E. coli
Michael Wacker,Dennis Linton,Paul G. Hitchen,Mihai Nita-Lazar,Stuart M. Haslam,Simon J. North,Maria Panico,Howard R. Morris,Anne Dell,Brendan W. Wren,Markus Aebi +10 more
TL;DR: It is demonstrated that a functional N-linked glycosylation pathway could be transferred into Escherichia coli and opened up the possibility of engineering permutations of recombinant glycan structures for research and industrial applications.
Journal ArticleDOI
Glycolipids as receptors for Bacillus thuringiensis crystal toxin.
Joel S. Griffitts,Stuart M. Haslam,Tinglu Yang,Stephan F. Garczynski,Barbara Mulloy,Howard R. Morris,Paul S. Cremer,Anne Dell,Michael J. Adang,Raffi V. Aroian +9 more
TL;DR: It is demonstrated that the major mechanism for Bt toxin resistance in Caenorhabditis elegans entails a loss of glycolipid carbohydrates, and evidence that insect Glycolipids are also receptors for BT toxin is presented, showing carbohydrate-dependent and relevant for toxin action in vivo.
Journal ArticleDOI
Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome
Cory D. Rillahan,Aristotelis Antonopoulos,Craig T. Lefort,Roberto Sonon,Parastoo Azadi,Klaus Ley,Anne Dell,Stuart M. Haslam,James C. Paulson +8 more
TL;DR: It is shown that fluorinated analogs of sialic acid and fucose can be taken up and metabolized to the desired donor substrate-based inhibitors inside the cell, resulting in a global, family-wide shutdown of sIALyl- and/or fucosyltransferases and remodeling of cell-surface glycans.
Journal ArticleDOI
Host and viral determinants of influenza A virus species specificity.
TL;DR: The host barriers that influenza A viruses of animals, especially birds, must overcome to initiate a pandemic in humans are examined and how, on crossing the species barrier, the virus mutates to establish new interactions with the human host is described.