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Charlotte Hedin
Researcher at Karolinska University Hospital
Publications - 48
Citations - 1722
Charlotte Hedin is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Medicine & Inflammatory bowel disease. The author has an hindex of 16, co-authored 29 publications receiving 1315 citations. Previous affiliations of Charlotte Hedin include King's College London & Queen Mary University of London.
Papers
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Journal ArticleDOI
Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease
Jane L. Benjamin,Charlotte Hedin,Andreas Koutsoumpas,Siew C. Ng,Siew C. Ng,Neil E. McCarthy,Ailsa Hart,Michael A. Kamm,Jeremy D. Sanderson,Stella C. Knight,Alastair Forbes,Andrew J. Stagg,Kevin Whelan,James O. Lindsay +13 more
TL;DR: An adequately powered placebo-controlled trial of FOS showed no clinical benefit in patients with active Crohn's disease, despite impacting on DC function.
Journal ArticleDOI
Evidence for the use of probiotics and prebiotics in inflammatory bowel disease: a review of clinical trials.
TL;DR: The present article addresses the clinical evidence for the therapeutic manipulation of bowel microbiota using probiotics, prebiotics and synbiotics in IBD and reviews the role of the intestinal microbiota in the pathogenesis of IBD.
Journal ArticleDOI
Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota.
Jane L. Benjamin,Charlotte Hedin,Andreas Koutsoumpas,Siew C. Ng,Siew C. Ng,Neil E. McCarthy,Natalie J. Prescott,Pedro Pessoa-Lopes,Christopher G. Mathew,Jeremy D. Sanderson,Ailsa Hart,Michael A. Kamm,Michael A. Kamm,Stella C. Knight,Alastair Forbes,Andrew J. Stagg,James O. Lindsay,Kevin Whelan +17 more
TL;DR: Investigation of the association between smoking and the intestinal microbiota in patients with active Crohn's disease found that smokers have luminal microbiota that consist of significantly higher bacteroides.
Journal ArticleDOI
Increased Intestinal Permeability Is Associated With Later Development of Crohn's Disease.
Williams Turpin,Williams Turpin,Sun-Ho Lee,Sun-Ho Lee,Juan Antonio Raygoza Garay,Juan Antonio Raygoza Garay,Karen L. Madsen,Jonathan B. Meddings,Larbi Bedrani,Namita Power,Osvaldo Espin-Garcia,Wei Xu,Michelle I. Smith,Anne M. Griffiths,Paul Moayyedi,Dan Turner,Ernest G. Seidman,A. Hillary Steinhart,A. Hillary Steinhart,John Marshall,Kevan Jacobson,David R. Mack,Hien Q. Huynh,Charles N. Bernstein,Andrew D. Paterson,Maria T. Abreu,Paul L. Beck,Charles Bernstein,Kenneth Croitoru,Leo Dieleman,Brian G. Feagan,Anne Griffiths,David S. Guttman,Gilaad G. Kaplan,D.O. Krause,Karen Madsen,John Marshall,Mark J. Ropeleski,Ernest G Seidman,Mark S. Silverberg,Scott B. Snapper,Andy Stadnyk,Hillary Steinhart,Michael G. Surette,Thomas D. Walters,Bruce A. Vallance,Guy Aumais,Alain Bitton,Maria Cino,Jeff Critch,Lee A. Denson,Colette Deslandres,Wael El-Matary,Hans H Herfarth,Peter D.R. Higgins,Jeff Hyams,Jerry McGrath,Anthony R. Otley,Remo Panancionne,Robert Baldassano,Charlotte Hedin,Seamus Hussey,Hien Hyams,David J. Keljo,David Kevans,Charlie W. Lees,Sanjay K. Murthy,Remo Panaccione,Nimisha K. Parekh,Sophie Plamondon,Graham L. Radford-Smith,Joel R. Rosh,David T. Rubin,Michael Schultz,Corey A. Siegel +74 more
TL;DR: Findings support a model in which altered intestinal barrier function contributes to pathogenesis, and suggest abnormal gut barrier function might serve as a biomarker for risk of CD onset.
Journal ArticleDOI
Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings
Charlotte Hedin,Neil E. McCarthy,Petra Louis,Freda M. Farquharson,Sara McCartney,Kirstin M. Taylor,Natalie J. Prescott,Trevor Murrells,Andrew J. Stagg,Kevin Whelan,James O. Lindsay +10 more
TL;DR: Healthy siblings of patients with CD manifest immune and microbiological abnormalities associated with CD distinct from their genotype-related risk and provide an excellent model in which to investigate early CD pathogenesis.