Charlotte Mezö

TL;DR: This paper found that the immature phenotype of microglia from germ-free (GF) mice is epigenetically imprinted by H3K4me3 and H3k9ac on metabolic genes associated with substantial functional alterations including increased mitochondrial mass and specific respiratory chain dysfunctions.

TL;DR: In this article, it was shown that Aβ entered WT grafts, and that this was accompanied by microglia infiltration in the vicinity of amyloid beta (Aβ) plaques.

TL;DR: It is observed that constitutive or induced microbiota modulation in 5xFAD mice differentially controls microglial Aβ clearance mechanisms preventing neurodegeneration and cognitive deficits.

TL;DR: It is found that the microbiota influenced aging associated-changes in microglial gene expression and a microbiota-dependent increase in intestinal permeability in aged mice mediated the elevated levels of N6-carboxymethyllysine.

TL;DR: In this paper, the effects of microbiota on the central nervous system (CNS) myeloid cell composition and function were investigated by combining several microbiota manipulation approaches, genetic mouse models, and single-cell RNA sequencing.