Matteo Villa

TL;DR: It is shown that acute inhibition of this pathway blunts OXPHOS-dependent alternative activation, while leaving aerobic glycolysis-dependent classical activation intact, which might have implications for therapeutically controlling macrophage activation by targeting the polyamine-eIF5A-hypusine axis.

TL;DR: Hyporesponsive T cells can be epigenetically remodeled and reactivated by acetate, suggesting that pathways regulating the use of substrates alternative to glucose could be therapeutically targeted to promote T cell function during cancer.

TL;DR: This paper found that the immature phenotype of microglia from germ-free (GF) mice is epigenetically imprinted by H3K4me3 and H3k9ac on metabolic genes associated with substantial functional alterations including increased mitochondrial mass and specific respiratory chain dysfunctions.

TL;DR: The literature is surveyed and recent advances in understanding of several ancillary metabolic pathways and how they support processes beyond ATP production and ultimately contribute to protective immunity are highlighted.

TL;DR: This article showed that polyamine metabolism is a fundamental process governing the ability of CD4+ helper T cells (TH) to polarize into different functional fates, and that polyamines control TH differentiation by providing substrates for deoxyhypusine synthase, which synthesizes the amino acid hypusine.