C
Cheng S. Jin
Researcher at Princess Margaret Cancer Centre
Publications - 26
Citations - 2867
Cheng S. Jin is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Photothermal therapy & Photodynamic therapy. The author has an hindex of 17, co-authored 26 publications receiving 2473 citations. Previous affiliations of Cheng S. Jin include University Health Network & University of Toronto.
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Journal ArticleDOI
Nanoparticle‐Enabled, Image‐Guided Treatment Planning of Target Specific RNAi Therapeutics in an Orthotopic Prostate Cancer Model
TL;DR: A multimodal theranostic lipid-nanoparticle, HPPS(NIR)-chol-siRNA, which has a near-infrared (NIR) fluorescent core, enveloped by phospholipid monolayer, intercalated with siRNA payloads, and constrained by apoA-I mimetic peptides to give ultra-small particle size (<30 nm).
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Nanoparticle targeted folate receptor 1-enhanced photodynamic therapy for lung cancer.
Tatsuya Kato,Cheng S. Jin,Hideki Ujiie,Daiyoon Lee,Kosuke Fujino,Hironobu Wada,Hsin-pei Hu,Robert A. Weersink,Juan Chen,Mitsuhito Kaji,Kichizo Kaga,Yoshiro Matsui,Brian C. Wilson,Gang Zheng,Kazuhiro Yasufuku +14 more
TL;DR: Folate-porphysome based PDT shows promise in selectively ablating lung cancer based on FOLR1 expression in these preclinical models and was highly expressed in metastatic lymph node samples from patients with advanced lung cancer.
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Multimodal Image-Guided Surgical and Photodynamic Interventions in Head and Neck Cancer: From Primary Tumor to Metastatic Drainage
Nidal Muhanna,Liyang Cui,Harley Chan,Laura Burgess,Cheng S. Jin,Thomas D. MacDonald,Elizabeth Huynh,Fan Wang,Juan Chen,Jonathan C. Irish,Gang Zheng +10 more
TL;DR: PLPs provide a multimodal imaging and therapy platform that could enhance HNC diagnosis by integrating PET/computed tomography and fluorescence imaging, and improve HNC therapeutic efficacy and specificity by tailoring treatment via fluorescence-guided surgery and PDT.
Journal ArticleDOI
Cell-Free DNA Kinetics in a Pre-Clinical Model of Head and Neck Cancer
Nidal Muhanna,Nidal Muhanna,Marco A. Di Grappa,Harley H.L. Chan,Tahsin Khan,Cheng S. Jin,Yangqiao Zheng,Jonathan C. Irish,Jonathan C. Irish,Scott V. Bratman,Scott V. Bratman +10 more
TL;DR: CtDNA kinetics within an orthotopic, immunocompetent preclinical rabbit model of local-regionally advanced head and neck squamous cell carcinoma is described, revealing the complex kinetic behaviour of ctDNA and total plasma DNA upon tumour growth or surgery.
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Nanotexaphyrin: One-Pot Synthesis of a Manganese Texaphyrin-Phospholipid Nanoparticle for Magnetic Resonance Imaging.
Joseph M. Keca,Joseph M. Keca,Juan Chen,Marta Overchuk,Marta Overchuk,Nidal Muhanna,Christina M. MacLaughlin,Cheng S. Jin,Warren D. Foltz,Jonathan C. Irish,Gang Zheng +10 more
TL;DR: Synthesis of 17 additional metallo-texaphyrin building blocks suggests that this novel one-pot synthetic procedure for nanotexaphyrins may lead to a wide range of applications in the field of nanomedicines.