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Cheryl C. Y. Li
Researcher at Victor Chang Cardiac Research Institute
Publications - 9
Citations - 573
Cheryl C. Y. Li is an academic researcher from Victor Chang Cardiac Research Institute. The author has contributed to research in topics: Epigenetics & Offspring. The author has an hindex of 8, co-authored 9 publications receiving 516 citations. Previous affiliations of Cheryl C. Y. Li include Royal Prince Alfred Hospital & University of Sydney.
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Journal ArticleDOI
Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells
Cheryl C. Y. Li,Sally A. Eaton,Paul E. Young,Maggie Lee,Rupert Shuttleworth,David T. Humphreys,Georges E. Grau,Valery Combes,Mary Bebawy,Joyce Gong,Susan Brammah,Michael E. Buckland,Catherine M. Suter +12 more
TL;DR: It is found that glioma microvesicles are predominantly of exosomal origin and contain complex populations of coding and noncoding RNAs in proportions that are distinct from those in the cells from which they are derived.
Journal ArticleDOI
Maternal obesity and diabetes induces latent metabolic defects and widespread epigenetic changes in isogenic mice.
Cheryl C. Y. Li,Paul E. Young,Christopher A. Maloney,Sally A. Eaton,Mark J. Cowley,Michael E. Buckland,Thomas Preiss,Darren C. Henstridge,Gregory J. Cooney,Mark A. Febbraio,David I. K. Martin,Jennifer E. Cropley,Catherine M. Suter +12 more
TL;DR: The offspring of obese mothers have a latent metabolic phenotype that is unmasked by exposure to a Western-style diet, resulting in glucose intolerance, insulin resistance and hepatic steatosis, the first study of the epigenomic consequences of exposure to maternal obesity and diabetes is performed.
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A sustained dietary change increases epigenetic variation in isogenic mice
Cheryl C. Y. Li,Jennifer E. Cropley,Jennifer E. Cropley,Mark J. Cowley,Thomas Preiss,Thomas Preiss,David I. K. Martin,Catherine M. Suter,Catherine M. Suter +8 more
TL;DR: Assessing genomic CpG methylation patterns in isogenic mice exposed for one or six generations finds stochastic variation in methylation levels at many loci; exposure to methyl donors increases the magnitude of this variation and the number of variable loci, suggesting that some of the induced changes are heritable.
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Epigenetic programming by maternal nutrition: shaping future generations.
Cheryl C. Y. Li,Christopher A. Maloney,Christopher A. Maloney,Jennifer E. Cropley,Jennifer E. Cropley,Catherine M. Suter +5 more
TL;DR: Epigenetics as a mediator of disease risk in response to nutritional cues is discussed and the potential for maternal nutrition to heritably alter epigenetic states may have implications for population health and adaptive evolution.
Journal ArticleDOI
Oligoastrocytomas: throwing the baby out with the bathwater?
Paul Wilcox,Cheryl C. Y. Li,Cheryl C. Y. Li,Maggie Lee,Maggie Lee,Brindha Shivalingam,Jeffrey Brennan,Catherine M. Suter,Kimberley L. Kaufman,Kimberley L. Kaufman,Trina Lum,Michael E. Buckland,Michael E. Buckland +12 more
TL;DR: It is proposed that in 30 cases diagnosed as OA, immunostain-ing for IDH1 (R132H) mutation was restricted to oligo-dendroglial areas only, which indicates that ‘ true’ OAs (i.e. ‘true’ tumours com-posed of two distinct) are not found.