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Darren C. Henstridge
Researcher at RMIT University
Publications - 96
Citations - 6595
Darren C. Henstridge is an academic researcher from RMIT University. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 35, co-authored 94 publications receiving 5384 citations. Previous affiliations of Darren C. Henstridge include Monash University, Clayton campus & The Heart Research Institute.
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Journal ArticleDOI
HSP72 protects against obesity-induced insulin resistance.
Jason Chung,Anh-Khoi Nguyen,Darren C. Henstridge,Anna G Holmes,Stanley M H Chan,Jose L Mesa,Grame I I Lancaster,Robert J Southgate,Clinton R. Bruce,Stephen J. Duffy,Ibolya Horváth,Ruben Mestril,Matthew J. Watt,Philp L Hooper,Bronwyn A. Kingwell,László Vígh,Andrea L. Hevener,Andrea L. Hevener,Mark A. Febbraio +18 more
TL;DR: An essential role is identified for HSP72 in blocking inflammation and preventing insulin resistance in the context of genetic obesity or high-fat feeding and protection against diet- or obesity-induced hyperglycemia, hyperinsulinemia, glucose intolerance, and insulin resistance.
Journal ArticleDOI
Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding
Nigel Turner,Nigel Turner,Grzegorz M Kowalski,Grzegorz M Kowalski,Simon J Leslie,Steve Risis,Christine Yang,Robert S. Lee-Young,Joanne R Babb,Peter J. Meikle,Graeme I. Lancaster,Darren C. Henstridge,Phillip J. White,Edward W. Kraegen,Edward W. Kraegen,André Marette,Gregory J. Cooney,Gregory J. Cooney,Mark A. Febbraio,Clinton R. Bruce,Clinton R. Bruce +20 more
TL;DR: HFD-induced whole-body insulin resistance is initiated by impaired hepatic insulin action and exacerbated by skeletal muscle insulin resistance and is associated with the accumulation of specific bioactive lipid species.
Journal ArticleDOI
High-Density Lipoprotein Modulates Glucose Metabolism in Patients With Type 2 Diabetes Mellitus
Brian G. Drew,Stephen J. Duffy,Melissa F. Formosa,Alaina K. Natoli,Darren C. Henstridge,Darren C. Henstridge,Sally A. Penfold,Walter G. Thomas,Nigora Mukhamedova,Barbora de Courten,Josephine M. Forbes,Felicia Y. T. Yap,David M. Kaye,Gerrit van Hall,Mark A. Febbraio,Bruce E. Kemp,Dmitri Sviridov,Gregory R. Steinberg,Bronwyn A. Kingwell +18 more
TL;DR: In this paper, a double-blind, placebo-controlled crossover study was conducted on 13 patients with type 2 diabetes mellitus who received both intravenous reconstituted HDL (rHDL: 80 mg/kg over 4 hours) and placebo on separate days in a double blind, placebo controlled crossover study.
Journal ArticleDOI
Correction: Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
Simone M. Schoenwaelder,Roxane Darbousset,Susan L. Cranmer,Hayley S. Ramshaw,Stephanie L. Orive,Sharelle Anne Sturgeon,Yuping Yuan,Yu Yao,James R. Krycer,Joanna M. Woodcock,Jessica Maclean,Stuart M. Pitson,Zhaohua Zheng,Darren C. Henstridge,Dianne E. van der Wal,Elizabeth E. Gardiner,Michael C. Berndt,Robert K. Andrews,David E. James,Angel F. Lopez,Shaun P. Jackson +20 more
TL;DR: This corrects the article DOI: 10.1038/ncomms12862 to Ncomms 12862 rather than NCOMMS 12863, which is closer to the truth.
Journal ArticleDOI
Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance
Vance B. Matthews,Tamara L Allen,Steve Risis,M. H S Chan,Darren C. Henstridge,Nadine Watson,L A Zaffino,Jenny R Babb,James Yew Chong Boon,Peter J. Meikle,Jeremy B. M. Jowett,Matthew J. Watt,John-Olov Jansson,Clinton R. Bruce,Mark A. Febbraio +14 more
TL;DR: The data suggest that IL-6 deficiency exacerbates HFD-induced hepatic insulin resistance and inflammation, a process that appears to be related to defects in mitochondrial metabolism.