C
Chin Wen Png
Researcher at National University of Singapore
Publications - 33
Citations - 2928
Chin Wen Png is an academic researcher from National University of Singapore. The author has contributed to research in topics: Colitis & Medicine. The author has an hindex of 15, co-authored 27 publications receiving 2383 citations. Previous affiliations of Chin Wen Png include Mater Health Services & University of Queensland.
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Journal ArticleDOI
Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria.
Chin Wen Png,Sara K. Lindén,Kristen Gilshenan,Erwin G. Zoetendal,Christopher S. McSweeney,Lindsay I. Sly,Michael A. McGuckin,Timothy H. Florin +7 more
TL;DR: Increased total mucosa-associated bacteria 16S rRNA gene in macroscopically and histologically normal intestinal epithelium of both Crohn's disease and ulcerative colitis confirmed, which suggests the possibility of an increased source of digestible endogenous mucus substrate.
Journal ArticleDOI
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis.
Chad K. Heazlewood,Matthew C. Cook,Rajaraman Eri,Gareth Price,Sharyn B. Tauro,Douglas Taupin,David J. Thornton,Chin Wen Png,Tanya L. Crockford,Richard J. Cornall,Rachel J. Adams,Masato Kato,Keats Nelms,Nancy A. Hong,Timothy H. Florin,Christopher C. Goodnow,Michael A. McGuckin +16 more
TL;DR: It is demonstrated that mucin misfolding and ER stress initiate colitis in mice, and that ER stress-related mucin depletion could be a fundamental component of the pathogenesis of human colitis and that clinical studies combining genetics, ER stressed pathology and relevant environmental epidemiology are warranted.
Journal ArticleDOI
MUC1 cell surface mucin is a critical element of the mucosal barrier to infection
Julie L. McAuley,Sara K. Lindén,Chin Wen Png,Rebecca M. King,Helen L. Pennington,Sandra J. Gendler,Timothy H. Florin,Geoff R. Hill,Victoria Korolik,Michael A. McGuckin +9 more
TL;DR: It is believed that this is the first in vivo experimental study to demonstrate that cell surface mucins are a critical component of mucosal defence and that the study provides the foundation for exploration of their contribution to epithelial infectious and inflammatory diseases.
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An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity.
Rajaraman Eri,Rachel J. Adams,Thu V. Tran,Hui Tong,Hui Tong,Indrajit Das,DK Roche,Iulia Oancea,Chin Wen Png,Penny L. Jeffery,Graham L. Radford-Smith,Matthew C. Cook,Timothy H. Florin,Michael A. McGuckin +13 more
TL;DR: The Winnie primary epithelial defect results in complex multicytokine-mediated colitis involving both innate and adaptive immune components with a prominent IL-23/TH17 response, similar to that of human ulcerative colitis.
Journal ArticleDOI
The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis
Yong H. Sheng,Rohan Lourie,Sara K. Lindén,Penny L. Jeffery,Deborah Roche,Thu V. Tran,Chin Wen Png,Nigel J. Waterhouse,Philip Sutton,Timothy H. Florin,Michael A. McGuckin +10 more
TL;DR: Novel findings indicate a protective role for Muc13 in the colonic epithelium by inhibiting toxin-induced apoptosis and have important implications for intestinal infections, inflammatory diseases and the development of intestinal cancer.