M
Masato Kato
Researcher at Mater Health Services
Publications - 1
Citations - 656
Masato Kato is an academic researcher from Mater Health Services. The author has contributed to research in topics: Mucin & Colitis. The author has an hindex of 1, co-authored 1 publications receiving 578 citations.
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Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis.
Chad K. Heazlewood,Matthew C. Cook,Rajaraman Eri,Gareth Price,Sharyn B. Tauro,Douglas Taupin,David J. Thornton,Chin Wen Png,Tanya L. Crockford,Richard J. Cornall,Rachel J. Adams,Masato Kato,Keats Nelms,Nancy A. Hong,Timothy H. Florin,Christopher C. Goodnow,Michael A. McGuckin +16 more
TL;DR: It is demonstrated that mucin misfolding and ER stress initiate colitis in mice, and that ER stress-related mucin depletion could be a fundamental component of the pathogenesis of human colitis and that clinical studies combining genetics, ER stressed pathology and relevant environmental epidemiology are warranted.