D
Douglas Taupin
Researcher at Canberra Hospital
Publications - 15
Citations - 2540
Douglas Taupin is an academic researcher from Canberra Hospital. The author has contributed to research in topics: Trefoil factor 2 & Trefoil factor 3. The author has an hindex of 12, co-authored 14 publications receiving 2333 citations. Previous affiliations of Douglas Taupin include Peter MacCallum Cancer Centre & Harvard University.
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Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis.
Chad K. Heazlewood,Matthew C. Cook,Rajaraman Eri,Gareth Price,Sharyn B. Tauro,Douglas Taupin,David J. Thornton,Chin Wen Png,Tanya L. Crockford,Richard J. Cornall,Rachel J. Adams,Masato Kato,Keats Nelms,Nancy A. Hong,Timothy H. Florin,Christopher C. Goodnow,Michael A. McGuckin +16 more
TL;DR: It is demonstrated that mucin misfolding and ER stress initiate colitis in mice, and that ER stress-related mucin depletion could be a fundamental component of the pathogenesis of human colitis and that clinical studies combining genetics, ER stressed pathology and relevant environmental epidemiology are warranted.
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Trefoil factors: initiators of mucosal healing
TL;DR: Maintaining the integrity of the gastrointestinal tract, despite the continual presence of microbial flora and injurious agents, is essential and depends on a family of small, yet abundant, secreted proteins — the trefoil factors.
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Intestinal trefoil factor confers colonic epithelial resistance to apoptosis
TL;DR: Findings support a central role for ITF in the maintenance of intestinal mucosal continuity, and demonstrate the potential of ITF expression to confer resistance of colorectal tumors to therapy.
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TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury
James J. Farrell,Douglas Taupin,Theodore J. Koh,Duan Chen,Chun-Mei Zhao,Daniel K. Podolsky,Timothy C. Wang,Timothy C. Wang +7 more
TL;DR: A physiologic role for TFF2 is suggested to promote mucosal healing through the stimulation of proliferation and downregulation of gastric acid secretion.
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Distinct Pathways of Cell Migration and Antiapoptotic Response to Epithelial Injury: Structure-Function Analysis of Human Intestinal Trefoil Factor
TL;DR: It is demonstrated that distinct intracellular signaling pathways mediate the effects of ITF on cell migration and apoptosis, and neither an intact trefoil domain nor dimerization was required to promote cell migration.