C
Chisayo Kozuka
Researcher at University of the Ryukyus
Publications - 30
Citations - 1137
Chisayo Kozuka is an academic researcher from University of the Ryukyus. The author has contributed to research in topics: Brown rice & Insulin resistance. The author has an hindex of 18, co-authored 26 publications receiving 828 citations. Previous affiliations of Chisayo Kozuka include Joslin Diabetes Center & Harvard University.
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Journal ArticleDOI
SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms.
Soravis Osataphan,Soravis Osataphan,Soravis Osataphan,Chiara Macchi,Chiara Macchi,Garima Singhal,Garima Singhal,Jeremy Chimene-Weiss,Vicencia Sales,Vicencia Sales,Chisayo Kozuka,Chisayo Kozuka,Jonathan M. Dreyfuss,Jonathan M. Dreyfuss,Hui Pan,Hui Pan,Yanin Tangcharoenpaisan,Jordan Morningstar,Robert E. Gerszten,Robert E. Gerszten,Mary-Elizabeth Patti,Mary-Elizabeth Patti +21 more
TL;DR: It is demonstrated that SGLT2 inhibition triggers a fasting-like transcriptional and metabolic paradigm but requires FGF21 for reduction in adiposity, and that CANA induces transcriptional reprogramming to activate catabolic pathways.
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Adipose Tissue–Specific Regulation of Angiotensinogen in Obese Humans and Mice: Impact of Nutritional Status and Adipocyte Hypertrophy
Shintaro Yasue,Hiroaki Masuzaki,Sadanori Okada,Takako Ishii,Chisayo Kozuka,Tomohiro Tanaka,Junji Fujikura,Ken Ebihara,Kiminori Hosoda,Akemi Katsurada,Naro Ohashi,Maki Urushihara,Hiroyuki Kobori,Naoki Morimoto,Takeshi Kawazoe,Motoko Naitoh,Mitsuru Okada,Hiroshi Sakaue,Hiroshi Sakaue,Shigehiko Suzuki,Kazuwa Nakao +20 more
TL;DR: Adipose tissue-specific regulation of AGT provides a novel insight into the clinical implications of adipose tissue RAS in human obesity and may contribute considerably to elevated levels of circulating AGT.
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Macrophage glucose-6-phosphate dehydrogenase stimulates proinflammatory responses with oxidative stress
Mira Ham,Joo-Won Lee,A Hyun Choi,Hagoon Jang,Goun Choi,Jiyoung Park,Chisayo Kozuka,Dorothy D. Sears,Hiroaki Masuzaki,Jae Bum Kim +9 more
TL;DR: Overexpression of macrophage G6PD potentiated the expression of proinflammatory and pro-oxidative genes responsible for the aggravation of insulin sensitivity in adipocytes, and an abnormal increase of G6 PD in macrophages promotes oxidative stress and inflammatory responses in the adipose tissue of obese animals.
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Brown Rice and Its Component, γ-Oryzanol, Attenuate the Preference for High-Fat Diet by Decreasing Hypothalamic Endoplasmic Reticulum Stress in Mice
Chisayo Kozuka,Kouichi Yabiku,Sumito Sunagawa,Rei Ueda,Shin-ichiro Taira,Hiroyuki Ohshiro,Tomomi Ikema,Ken Yamakawa,Moritake Higa,Hideaki Tanaka,Chitoshi Takayama,Masayuki Matsushita,Seiichi Oyadomari,Michio Shimabukuro,Hiroaki Masuzaki +14 more
TL;DR: This is the first demonstration that brown rice and Orz improve glucose metabolism, reduce hypothalamic ER stress, and, consequently, attenuate the preference for dietary fat in mice fed an HFD.
Journal ArticleDOI
Natural food science based novel approach toward prevention and treatment of obesity and type 2 diabetes: recent studies on brown rice and γ-oryzanol.
Chisayo Kozuka,Kouichi Yabiku,Chitoshi Takayama,Masayuki Matsushita,Michio Shimabukuro,Hiroaki Masuzaki +5 more
TL;DR: This paper found that one of the major components of brown rice, γ-oryzanol (Orz), plays an important role in the metabolically beneficial effects of brown Rice and showed that Orz acts as a chemical chaperone and decreases high fat diet (HFD)-induced endoplasmic reticulum (ER) stress in the hypothalamus.