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Chongzhuo Zhu
Researcher at Chinese Academy of Sciences
Publications - 6
Citations - 1749
Chongzhuo Zhu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Mitophagy & Mitochondrion. The author has an hindex of 5, co-authored 6 publications receiving 1303 citations.
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Journal ArticleDOI
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
Lei Liu,Du Feng,Guo Chen,Ming Chen,Qiaoxia Zheng,Pingping Song,Qi Ma,Chongzhuo Zhu,Rui Wang,Wanjun Qi,Lei Huang,Peng Xue,Baowei Li,Xiaohui Wang,Haijing Jin,Jun Wang,Fuquan Yang,Pingsheng Liu,Yushan Zhu,Sen-Fang Sui,Quan Chen,Quan Chen +21 more
TL;DR: It is reported that FUNDC1, an integral mitochondrial outer-membrane protein, is a receptor for hypoxia-induced mitophagy, and its findings offer insights into mitochondrial quality control in mammalian cells.
Journal ArticleDOI
Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy.
Ming Chen,Ziheng Chen,Yueying Wang,Zheng Tan,Chongzhuo Zhu,Yanjun Li,Zhe Han,Linbo Chen,Ruize Gao,Lei Liu,Quan Chen +10 more
TL;DR: The data suggest that FUNDC1 regulates both mitochondrial fission or fusion and mitophagy and mediates the “coupling” across the double membrane for mitochondrial dynamics and quality control.
Journal ArticleDOI
Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury
Weilin Zhang,He Ren,Chunling Xu,Chongzhuo Zhu,Hao Wu,Dong Liu,Jun Wang,Lei Liu,Li Wei,Qi Ma,Qi Ma,Lei Du,Ming Zheng,Chuanmao Zhang,Junling Liu,Quan Chen,Quan Chen +16 more
TL;DR: It is shown that manipulation of mitophagy by hypoxia or pharmacological approaches may be a novel strategy for cardioprotection and a new mechanism of the hypoxic preconditioning effect which reduces I/R injury.
Journal ArticleDOI
The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy
Hao Wu,Danfeng Xue,Guo Chen,Zhe Han,Li Huang,Chongzhuo Zhu,Xiaohui Wang,Haijing Jin,Jun Wang,Yushan Zhu,Lei Liu,Quan Chen +11 more
TL;DR: The striking finding that BCL2L1/Bcl-xL, but not BCL 2, suppresses mitophagy mediated by FUNDC1 through its BH3 domain is reported.
Journal ArticleDOI
Mitochondrial PIP3-binding protein FUNDC2 supports platelet survival via AKT signaling pathway.
Qi Ma,Chongzhuo Zhu,Weilin Zhang,Na Ta,Rong Zhang,Lei Liu,Du Feng,Heping Cheng,Junling Liu,Quan Chen +9 more
TL;DR: This FUNDC2/AKT/BCL-xL axis signifies a balance between platelet survival and apoptosis at the single organelle level and provides new insight for platelet-related diseases as well.