C
Chris Fox
Researcher at University of East Anglia
Publications - 301
Citations - 11432
Chris Fox is an academic researcher from University of East Anglia. The author has contributed to research in topics: Dementia & Randomized controlled trial. The author has an hindex of 49, co-authored 284 publications receiving 9541 citations. Previous affiliations of Chris Fox include University of Wollongong & University of Hull.
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Journal ArticleDOI
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
Diana Jurk,Caroline L. Wilson,João F. Passos,Fiona Oakley,Clara Correia-Melo,Laura C. Greaves,Gabriele Saretzki,Chris Fox,Conor Lawless,Rhys Anderson,Graeme Hewitt,Sylvia L.F. Pender,Nicola Fullard,Glyn Nelson,Jelena Mann,Bart van de Sluis,Derek A. Mann,Thomas von Zglinicki +17 more
TL;DR: It is shown that chronic, progressive low-grade inflammation induced by knockout of the nfkb1 subunit of the transcription factor NF-κB induces premature ageing in mice, and frequency of senescent cells in liver and intestinal crypts quantitatively predict mean and maximum lifespan in both short- and long-lived mice cohorts.
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Impact of anticholinergics on the aging brain: a review and practical application
TL;DR: Criteria for assessing anticholinergic burden with a simple scale may represent a useful noninvasive tool to optimize geriatric pharmacotherapy and establish therapeutic guidelines in the presence of cognitive antICHolinergic adverse effects.
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Anticholinergic medication use and cognitive impairment in the older population: the medical research council cognitive function and ageing study
Chris Fox,Kathryn Richardson,Ian Maidment,Ian Maidment,George M. Savva,Fiona E. Matthews,David G. Smithard,David G. Smithard,Simon Coulton,Cornelius Katona,Malaz Boustani,Carol Brayne +11 more
TL;DR: Whether the use of medications with possible and definite anticholinergic activity increases the risk of cognitive impairment and mortality in older people and whether risk is cumulative is investigated.
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Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial
Sube Banerjee,Jennifer Hellier,Michael E. Dewey,Renee Romeo,Clive Ballard,Robert Baldwin,Peter Bentham,Chris Fox,Clive Holmes,Cornelius Katona,Martin Knapp,Claire Lawton,James Lindesay,Gill Livingston,Niall McCrae,Esme Moniz-Cook,Joanna Murray,Shirley Nurock,Martin Orrell,John T. O'Brien,Michaela Poppe,Alan J. Thomas,Rebecca Walwyn,Kenneth Wilson,Alistair Burns +24 more
TL;DR: Because of the absence of benefit compared with placebo and increased risk of adverse events, the present practice of use of these antidepressants, with usual care, for first-line treatment of depression in Alzheimer's disease should be reconsidered.
Journal ArticleDOI
The cognitive impact of anticholinergics: a clinical review.
Noll L. Campbell,Malaz Boustani,Tony Limbil,Carol A. Ott,Chris Fox,Ian Maidment,Cathy C. Schubert,Stephanie Munger,Donna M. Fick,David C. Miller,Rajesh Gulati +10 more
TL;DR: All but two studies found an association between the anticholinergic activity of medications and either delirium, cognitive impairment or dementia, and recognition of certain medications may represent a potential tool to improve cognition.