B
Bart van de Sluis
Researcher at University Medical Center Groningen
Publications - 90
Citations - 10769
Bart van de Sluis is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Inflammation & LDL receptor. The author has an hindex of 39, co-authored 90 publications receiving 7992 citations. Previous affiliations of Bart van de Sluis include University of Adelaide & University Medical Center Utrecht.
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Journal ArticleDOI
Clearance of p16 Ink4a -positive senescent cells delays ageing-associated disorders
Darren J. Baker,Tobias Wijshake,Tamar Tchkonia,Nathan K. LeBrasseur,Bennett G. Childs,Bart van de Sluis,James L. Kirkland,Jan M. van Deursen +7 more
TL;DR: Data indicate that cellular senescence is causally implicated in generating age-related phenotypes and that removal of senescent cells can prevent or delay tissue dysfunction and extend healthspan.
Journal ArticleDOI
Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel
Brian A. Ference,Henry N. Ginsberg,Ian D. Graham,Kausik K. Ray,Chris J. Packard,Eric Bruckert,Robert A. Hegele,Ronald M. Krauss,Frederick J. Raal,Heribert Schunkert,Gerald F. Watts,Jan Borén,Sergio Fazio,Jay D. Horton,Luis Masana,Stephen J. Nicholls,Børge G. Nordestgaard,Børge G. Nordestgaard,Bart van de Sluis,Marja-Riitta Taskinen,Lale Tokgozoglu,Ulf Landmesser,Ulf Landmesser,Ulf Landmesser,Ulrich Laufs,Olov Wiklund,Olov Wiklund,Jane K Stock,M. John Chapman,Alberico L. Catapano +29 more
TL;DR: Consistent evidence from numerous and multiple different types of clinical and genetic studies unequivocally establishes that LDL causes ASCVD.
Journal ArticleDOI
Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel
Jan Borén,M. John Chapman,M. John Chapman,Ronald M. Krauss,Chris J. Packard,Jacob F. Bentzon,Jacob F. Bentzon,Christoph J. Binder,Mat J.A.P. Daemen,Linda L. Demer,Robert A. Hegele,Stephen J. Nicholls,Børge G. Nordestgaard,Gerald F. Watts,Gerald F. Watts,Eric Bruckert,Sergio Fazio,Brian A. Ference,Brian A. Ference,Ian D. Graham,Jay D. Horton,Ulf Landmesser,Ulrich Laufs,Luis Masana,Gerard Pasterkamp,Frederick J. Raal,Kausik K. Ray,Heribert Schunkert,Marja-Riitta Taskinen,Bart van de Sluis,Olov Wiklund,Lale Tokgozoglu,Alberico L. Catapano,Henry N. Ginsberg +33 more
TL;DR: In this paper, the authors proposed a method to solve the problem of the problem: this paper ] of "uniformity" of the distribution of data points in the data set.
Journal ArticleDOI
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
Diana Jurk,Caroline L. Wilson,João F. Passos,Fiona Oakley,Clara Correia-Melo,Laura C. Greaves,Gabriele Saretzki,Chris Fox,Conor Lawless,Rhys Anderson,Graeme Hewitt,Sylvia L.F. Pender,Nicola Fullard,Glyn Nelson,Jelena Mann,Bart van de Sluis,Derek A. Mann,Thomas von Zglinicki +17 more
TL;DR: It is shown that chronic, progressive low-grade inflammation induced by knockout of the nfkb1 subunit of the transcription factor NF-κB induces premature ageing in mice, and frequency of senescent cells in liver and intestinal crypts quantitatively predict mean and maximum lifespan in both short- and long-lived mice cohorts.
Journal ArticleDOI
Identification of a new copper metabolism gene by positional cloning in a purebred dog population.
TL;DR: The discovery of a mutated MURR1 gene in Bedlington terriers with copper toxicosis provides a new lead to disentangling the complexities of copper metabolism in mammals.