C
Christian G. Peace
Researcher at Trinity College, Dublin
Publications - 7
Citations - 124
Christian G. Peace is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Medicine & Chemistry. The author has co-authored 1 publications.
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Journal ArticleDOI
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages.
Marah C. Runtsch,Stefano Angiari,Alexander Hooftman,Ridhima Wadhwa,Yanling Zhang,Yunan Zheng,Joseph S Spina,Melanie Ruzek,Maria A. Argiriadi,Anne F. McGettrick,Rui Santalla Mendez,Alessia Zotta,Christian G. Peace,Aoife Walsh,Roberta Chirillo,Emily Hams,Padraic G. Fallon,Ranjith Jayamaran,Kamal Dua,Alexandra C. Brown,Richard Kim,Jay C. Horvat,Philip M. Hansbro,Chu Wang,L. O'Neill +24 more
TL;DR: Itaconate and 4-octyl itaconate (OI) were shown to suppress the inflammatory response in pro-inflammatory "M1" macrophages and inhibit metabolic remodeling as mentioned in this paper .
Journal ArticleDOI
The role of itaconate in host defense and inflammation
TL;DR: Itaconate and its derivatives have antiinflammatory effects in preclinical models of sepsis, viral infections, psoriasis, gout, ischemia/reperfusion injury, and pulmonary fibrosis, pointing to possible itaconate-based therapeutics for a range of inflammatory diseases.
Journal ArticleDOI
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production
Alexander Hooftman,Christian G. Peace,Dylan G. Ryan,Emily A. Day,Ming Yang,Anne F. McGettrick,Maureen Yin,Erica N. Montano,Lihong Huo,Juliana E Toller-Kawahisa,Vincent Zecchini,Tristram A. J. Ryan,Alfonso Bolado-Carrancio,Alva M. Casey,Hiran A. Prag,Ana S. H. Costa,Gabriela de los Santos,Mariko L. Ishimori,Daniel J. Wallace,Swamy Venuturupalli,Efterpi Nikitopoulou,Norma Frizzell,Cecilia Johansson,Alex von Kriegsheim,Michael P. Murphy,Caroline A. Jefferies,Christian Frezza,Luke A. J. O'Neill +27 more
TL;DR: In this article , an inflammatory shunt is induced following lipopolysaccharide stimulation, supported by increased argininosuccinate synthase (ASS1) expression and increased cytosolic fumarate levels.
Journal ArticleDOI
NLRP3, the inflammasome and COVID-19 infection.
TL;DR: The role of NLRP3 activation in severe coronavirus disease 2019 (COVID-19) is discussed in this paper , where clinical trials are being conducted to target the inflammasome.
Journal ArticleDOI
Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon
Tristram A. J. Ryan,Alexander Hooftman,Aisling M. Rehill,Matt D. Johansen,E. Timothy O' Brien,Juliana E Toller-Kawahisa,Mieszko M. Wilk,Emily A. Day,Hauke J Weiss,Pourya Sarvari,Emilio G. Vozza,Fabian Schramm,Christian G. Peace,Alessia Zotta,S. Miemczyk,Christina Nalkurthi,Nicole G. Hansbro,Gavin J. McManus,Laura O'Doherty,Siobhan Gargan,Aideen Long,Jean Dunne,Cliona Ni Cheallaigh,Niall Conlon,Michael Carey,Padraic G. Fallon,Kingston H. G. Mills,Emma M. Creagh,J M O Donnell,Paul J. Hertzog,Philip M. Hansbro,Rachel M. McLoughlin,Malgorzata Wygrecka,Roger J. S. Preston,Zbigniew Zaslona,Luke A Neill +35 more
TL;DR: In this paper , the authors identify the clinically approved drug DMF and the pre-clinical tool compound 4-OI as anticoagulants that inhibit TF-mediated coagulopathy via inhibition of the macrophage type I IFN-TF axis.