C
Christian Schuetz
Researcher at Harvard University
Publications - 31
Citations - 2166
Christian Schuetz is an academic researcher from Harvard University. The author has contributed to research in topics: Transplantation & Islet. The author has an hindex of 17, co-authored 31 publications receiving 1889 citations. Previous affiliations of Christian Schuetz include VA Boston Healthcare System.
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Journal ArticleDOI
Regeneration and orthotopic transplantation of a bioartificial lung
Harald C. Ott,Ben Clippinger,Claudius Conrad,Christian Schuetz,Irina Pomerantseva,Laertis Ikonomou,Darrell N. Kotton,Joseph P. Vacanti +7 more
TL;DR: Creation of a bioartificial lung requires engineering of viable lung architecture enabling ventilation, perfusion and gas exchange, and regenerated lungs into orthotopic position showed in vivo function.
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Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3
TL;DR: It is found that functional beta-cell maturation is marked by an increase in the glucose threshold for insulin secretion and by expression of the gene urocortin 3.
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PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes.
Moufida Ben Nasr,Moufida Ben Nasr,Sara Tezza,Francesca D'Addio,Francesca D'Addio,Chiara Mameli,Vera Usuelli,Vera Usuelli,Anna Maestroni,Domenico Corradi,Silvana Belletti,Luca Albarello,Gabriella Becchi,Gian Paolo Fadini,Christian Schuetz,James F. Markmann,Clive Wasserfall,Leonard I. Zon,Gian Vincenzo Zuccotti,Gian Vincenzo Zuccotti,Paolo Fiorina,Paolo Fiorina +21 more
TL;DR: It is demonstrated that hematopoietic stem and progenitor cells from NOD mice and diabetic patients express less PD-L1, which is a T cell inhibitory molecule, and targeting a specific immune checkpoint defect in HSPCs thus may contribute to establishing a cure for T1D.
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A Novel Clinically Relevant Strategy to Abrogate Autoimmunity and Regulate Alloimmunity in NOD Mice
Andrea Vergani,Francesca D'Addio,Mollie Jurewicz,Alessandra Petrelli,Alessandra Petrelli,Toshihiko Watanabe,Kaifeng Liu,Kenneth Law,Christian Schuetz,M. Carvello,M. Carvello,Elena Orsenigo,Shaoping Deng,Scott J. Rodig,Javeed M. Ansari,Carlo Staudacher,Reza Abdi,John M. Williams,James F. Markmann,Mark A. Atkinson,Mohamed H. Sayegh,Paolo Fiorina,Paolo Fiorina +22 more
TL;DR: The capacity to regulate alloimmunity and to abrogate the autoimmune response in NOD mice in different settings confirmed that prolonged mATG+CTLA4-Ig treatment is a clinically relevant strategy to translate to humans with type 1 diabetes.
Journal ArticleDOI
Changing Pattern of Organ Donation at a Single Center: Are Potential Brain Dead Donors Being Lost to Donation After Cardiac Death?
Reza F. Saidi,James Bradley,D. Greer,Richard S. Luskin,Kevin J. O’Connor,Francis L. Delmonico,Peter T. Kennealey,F. Pathan,Christian Schuetz,Nahel Elias,Dicken S.C. Ko,Tatsuo Kawai,Martin Hertl,Cosimi Ab,James F. Markmann +14 more
TL;DR: A retrospective examination of Massachusetts General Hospital records of all 201 donors from 1/1/98 to the 11/2008 noted an increase in utilization of aggressive neurological management over time, especially in the DCD group, and a significant increase in cardiovascular/cerebrovascular as cause of death.