L
Laertis Ikonomou
Researcher at Boston University
Publications - 51
Citations - 2847
Laertis Ikonomou is an academic researcher from Boston University. The author has contributed to research in topics: Induced pluripotent stem cell & Progenitor cell. The author has an hindex of 17, co-authored 43 publications receiving 2443 citations. Previous affiliations of Laertis Ikonomou include University at Buffalo & National Institutes of Health.
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Journal ArticleDOI
Regeneration and orthotopic transplantation of a bioartificial lung
Harald C. Ott,Ben Clippinger,Claudius Conrad,Christian Schuetz,Irina Pomerantseva,Laertis Ikonomou,Darrell N. Kotton,Joseph P. Vacanti +7 more
TL;DR: Creation of a bioartificial lung requires engineering of viable lung architecture enabling ventilation, perfusion and gas exchange, and regenerated lungs into orthotopic position showed in vivo function.
Journal ArticleDOI
Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells.
Tyler A. Longmire,Tyler A. Longmire,Laertis Ikonomou,Laertis Ikonomou,Finn Hawkins,Finn Hawkins,Constantina Christodoulou,Constantina Christodoulou,Yuxia Cao,Yuxia Cao,Jyh-Chang Jean,Jyh-Chang Jean,Letty W. Kwok,Letty W. Kwok,Hongmei Mou,Jayaraj Rajagopal,Steven S. Shen,Anne A. Dowton,Anne A. Dowton,Maria Paola Serra,Maria Paola Serra,Daniel J. Weiss,Michael D. Green,Hans-Willem Snoeck,Maria I. Ramirez,Maria I. Ramirez,Darrell N. Kotton,Darrell N. Kotton +27 more
TL;DR: It is demonstrated that purification and directed differentiation of primordial lung and thyroid progenitors derived from mouse embryonic stem cells (ESCs) can specify these cells efficiently from definitive endodermal precursors.
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Insect cell culture for industrial production of recombinant proteins
TL;DR: Insect cells used in conjunction with the baculovirus expression vector system (BEVS) are gaining ground rapidly as a platform for recombinant protein production, and engineering issues related to high-density culture are addressed in view of their relevance to large-scale culture.
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Synergistic interaction between Candida albicans and commensal oral streptococci in a novel in vitro mucosal model.
Patricia I. Diaz,Zhihong Xie,Takanori Sobue,Angela Thompson,Başak Bıyıkoğlu,Austin Ricker,Laertis Ikonomou,Anna Dongari-Bagtzoglou +7 more
TL;DR: Criteria of mucosal invasion by the biofilm microorganisms suggested that the esophageal mucosa is more permissive to invasion than the oral mucosa, suggesting the pathogenic potential of C. albicans is limited.
Journal ArticleDOI
Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells.
Anita A. Kurmann,Anita A. Kurmann,Maria Paola Serra,Maria Paola Serra,Finn Hawkins,Finn Hawkins,Scott A. Rankin,Munemasa Mori,Munemasa Mori,Inna Astapova,Soumya Ullas,Sui Lin,Mélanie Bilodeau,Janet Rossant,J. C. Jean,J. C. Jean,Laertis Ikonomou,Laertis Ikonomou,Robin R. Deterding,John M. Shannon,Aaron M. Zorn,Anthony N. Hollenberg,Darrell N. Kotton,Darrell N. Kotton +23 more
TL;DR: The regulatory mechanisms that underlie early thyroid organogenesis are uncovered and provide a significant step toward cell-based regenerative therapy for hypothyroidism.