Christiana Labermaier

TL;DR: The results further support the match/mismatch hypothesis of psychiatric disease and illustrate how mild or moderate aversive conditions during development can shape an individual to be optimally adapted to similar conditions later in life.

TL;DR: The findings highlight the importance of forebrain CRHR1 in modulating some of the anxiogenic effects of early‐life stress, and suggest that other neural circuits are also involved in the programming effects ofEarly‐ life stress on anxiety‐related behavior.

TL;DR: It is shown that the stress responsive co-chaperone FKBP5 regulates glucose metabolism in mice by modulating AS160 phosphorylation, glucose transporter expression and muscle glucose uptake.

TL;DR: This review proposes an optimized translational research strategy to overcome some of the major limitations in biomarker discovery and is confident that early transfer and integration of data between both species, ideally leading to mutual supportive evidence from both preclinical and clinical studies, are most suitable to addressSome of the obstacles of current depression research.

TL;DR: It is demonstrated that chronic stress induces hypophagia and weight loss, ultimately improving features arising from an obesogenic context, including glucose tolerance and levels of insulin and leptin, and indicates that Fkbp5 may represent a novel target in metabolic regulation.