Christine C. Winterbourn

TL;DR: These interactions are relevant not only to antioxidant defence but as part of a network of radical reactions that can regulate the oxidation state of glutathione and the extent of protein S-thiolation as well as acting as a source of superoxide and hydrogen peroxide.

TL;DR: The findings imply that oxidation of one active site affects the conformation of the second site and influences which intermediate forms of the protein are favored under different cellular conditions.

TL;DR: This study is instructive in showing that glutathione homeostasis can be modulated in a complex way by electrophile exposure, and incorporated all mechanisms for increasing GSH production and inhibiting GSSG reduction into a theoretical kinetic model and showed that with a complex interplay between them it is possible to simulate the effects of NOA on cellular glutathion.

TL;DR: A new delivery system using 2 ml/kg per day, infused for 6 hours from the first day of life, avoided loss during infusion and significantly improved plasma vitamin A and E levels during the first 28 days of life in very low birth weight infants.

TL;DR: In this paper, the authors investigated RclR, a transcriptional activator of the rclABC operon in Escherichia coli that has been shown to be specifically activated by reactive chlorine species.