C
Christine C. Winterbourn
Researcher at University of Otago
Publications - 217
Citations - 22780
Christine C. Winterbourn is an academic researcher from University of Otago. The author has contributed to research in topics: Hypochlorous acid & Myeloperoxidase. The author has an hindex of 72, co-authored 211 publications receiving 20079 citations. Previous affiliations of Christine C. Winterbourn include Health Science University & Gravida.
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Journal ArticleDOI
A curious case of cysteines in human peroxiredoxin I.
Ashu Mohammad,Reena V. Saini,Rakesh Kumar,Deepak Sharma,Neeraj K. Saini,Arpit Gupta,Priyanka Thakur,Christine C. Winterbourn,Adesh K. Saini +8 more
TL;DR: Interestingly, hPrxI increases the expression of antioxidant genes, GPX1 and SOD1, and this is also seen in the case of a catalytic mutant, indicating h prxI can indirectly reduce oxidative stress independently of its own peroxidase function and thus suggesting a novel role of hPrzI in altering the expressionof other antioxidant genes.
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Redox regulation of neutrophil function.
TL;DR: This work has observed nuclear translocation of this transcription factor in neutrophils present in inflammatory exudates and observed changes in the expression of several hundred neutrophil genes during bacterial phagocytosis, which is indeed remarkable for a cell under extreme oxidative stress and destined to die within an hour or two.
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Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation.
Raphael F Queiroz,Raphael F Queiroz,Christopher P. Stanley,Christopher P. Stanley,Kathryn Wolhuter,Stephanie M Y Kong,Ragul Rajivan,Naomi McKinnon,Giang T H Nguyen,Antonella Roveri,Sebastian Guttzeit,Philip Eaton,William A. Donald,Fulvio Ursini,Christine C. Winterbourn,Anita Ayer,Anita Ayer,Anita Ayer,Roland Stocker +18 more
TL;DR: The authors showed that arterial glutathione peroxidases and peroxiredoxins that rapidly eliminate H2O2, have little impact on relaxation of IDO1-expressing arteries.
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Deciphering the in vivo redox behavior of human peroxiredoxins I and II by expressing in budding yeast.
Rakesh Kumar,Ashu Mohammad,Reena V. Saini,Anterpreet Chahal,Chi Ming Wong,Deepak Sharma,Sukhvir Kaur,Vikas Kumar,Christine C. Winterbourn,Adesh K. Saini +9 more
TL;DR: Resistance to oxidative stress of yeast cells expressing individual hPrxs requires the Prx to be maintained in a redox state that permits redox cycling and peroxidase activity.
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A monoclonal antibody recognizing the chlorohydrin derivatives of oleic acid for probing hypochlorous acid involvement in tissue injury.
TL;DR: The mAb CH-1 described here may be a useful probe for assessing the involvement of hypochlorous acid in tissue injury.