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Christine L. Laliberté
Researcher at Montreal Neurological Institute and Hospital
Publications - 19
Citations - 1265
Christine L. Laliberté is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Protein kinase A & Mutant. The author has an hindex of 15, co-authored 19 publications receiving 1134 citations.
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Journal ArticleDOI
Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity
Jacob Ellegood,Evdokia Anagnostou,Brooke A. Babineau,Jacqueline N. Crawley,Jacqueline N. Crawley,Lulu Lin,Matthieu Genestine,Emanuel DiCicco-Bloom,Jonathan Lai,Jane A. Foster,O Peñagarikano,Daniel H. Geschwind,Laura K. K. Pacey,David R. Hampson,Christine L. Laliberté,Alea A. Mills,Elaine Tam,Lucy R. Osborne,Mehreen Kouser,F. Espinosa-Becerra,Zhong Xuan,Craig M. Powell,Armin Raznahan,Diane M. Robins,Nobuhiro Nakai,J Nakatani,Toru Takumi,M. C. van Eede,T M Kerr,Christopher L. Muller,Randy D. Blakely,Jeremy Veenstra-VanderWeele,R. M. Henkelman,Jason P. Lerch +33 more
TL;DR: MRI-based phenotyping identified previously unknown connections between Nrxn1α, En2 and Fmr1; Nlgn3, BTBR and Slc6A4; and also between X monosomy and Mecp2, which can be linked to the under and over-connectivity found in autism.
Journal ArticleDOI
Abnormalities in brain structure and behavior in GSK-3alpha mutant mice
Oksana Kaidanovich-Beilin,Tatiana V. Lipina,Keizo Takao,Matthijs C. van Eede,Satoko Hattori,Christine L. Laliberté,Mustafa Khan,Kenichi Okamoto,Kenichi Okamoto,John W. Chambers,Paul J. Fletcher,Katrina MacAulay,Bradley W. Doble,R. Mark Henkelman,Tsuyoshi Miyakawa,John C. Roder,John C. Roder,James R. Woodgett,James R. Woodgett +18 more
TL;DR: A role for the GSK-3α gene in CNS functioning and possible involvement in the development of psychiatric disorders is supported by a well-established battery of behavioral tests together with neurochemical and neuroanatomical analysis.
Journal ArticleDOI
ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3.
Srinivasa Subramaniam,Ute Zirrgiebel,Oliver von Bohlen und Halbach,Jens Strelau,Christine L. Laliberté,David L. Kaplan,Klaus Unsicker +6 more
TL;DR: The data identify ERK as an important executor of neuronal damage involving a caspase-3–independent mechanism, allowing the distinction between plasma membrane (PM)–, DNA-, and PM/DNA-damaged populations.
Journal ArticleDOI
Preparation of fixed mouse brains for MRI.
Lindsay S. Cahill,Christine L. Laliberté,Jacob Ellegood,Shoshana Spring,Jacqueline A. Gleave,Matthijs C. van Eede,Jason P. Lerch,R. Mark Henkelman +7 more
TL;DR: Two fixation artifacts are described and their causes are identified: a hyperintense rim around the brain is observed when using perfusates reconstituted from powder and delivered at a high flow rate and gray-white matter contrast inversion is observedwhen too short a fixation time or too low a concentration of fixative is used, resulting in inadequate fixation.
Journal ArticleDOI
Insulin-Like Growth Factor 1 Inhibits Extracellular Signal-Regulated Kinase to Promote Neuronal Survival via the Phosphatidylinositol 3-Kinase/Protein Kinase A/c-Raf Pathway
Srinivasa Subramaniam,Neelam Shahani,Jens Strelau,Christine L. Laliberté,Roland Brandt,David L. Kaplan,Klaus Unsicker +6 more
TL;DR: It is demonstrated that IGF-1 can positively and negatively regulate the ERK pathway in the same neuronal cell, and new insights into the PI3K/Akt/PKA signaling pathways in IGF- 1-mediated neuronal survival are provided.