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Christopher L. Muller
Researcher at Vanderbilt University
Publications - 13
Citations - 1409
Christopher L. Muller is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Serotonin transporter & Serotonin. The author has an hindex of 13, co-authored 13 publications receiving 1216 citations. Previous affiliations of Christopher L. Muller include Duke University & Allen Institute for Brain Science.
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Journal ArticleDOI
The serotonin system in autism spectrum disorder: From biomarker to animal models.
TL;DR: Genetic linkage and association studies of whole blood serotonin levels and of ASD risk point to the chromosomal region containing the serotonin transporter (SERT) gene in males but not in females, and mouse models suggest an important role for the serotonin system in social behavior, in cognitive flexibility, and in sensory development.
Journal ArticleDOI
Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior.
Jeremy Veenstra-VanderWeele,Christopher L. Muller,Hideki Iwamoto,Jennifer E. Sauer,W. Anthony Owens,Charisma R. Shah,Jordan Cohen,Padmanabhan Mannangatti,Tammy Jessen,Brent J. Thompson,Ran Ye,Travis M. Kerr,Ana Carneiro,Jacqueline N. Crawley,Elaine Sanders-Bush,Douglas G. McMahon,Sammanda Ramamoorthy,Lynette C. Daws,James S. Sutcliffe,Randy D. Blakely +19 more
TL;DR: These efforts provide strong support for the hypothesis that altered 5-HT homeostasis can impact risk for ASD traits and provide a model with construct and face validity that can support further analysis of ASD mechanisms and potentially novel treatments.
Journal ArticleDOI
Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity
Jacob Ellegood,Evdokia Anagnostou,Brooke A. Babineau,Jacqueline N. Crawley,Jacqueline N. Crawley,Lulu Lin,Matthieu Genestine,Emanuel DiCicco-Bloom,Jonathan Lai,Jane A. Foster,O Peñagarikano,Daniel H. Geschwind,Laura K. K. Pacey,David R. Hampson,Christine L. Laliberté,Alea A. Mills,Elaine Tam,Lucy R. Osborne,Mehreen Kouser,F. Espinosa-Becerra,Zhong Xuan,Craig M. Powell,Armin Raznahan,Diane M. Robins,Nobuhiro Nakai,J Nakatani,Toru Takumi,M. C. van Eede,T M Kerr,Christopher L. Muller,Randy D. Blakely,Jeremy Veenstra-VanderWeele,R. M. Henkelman,Jason P. Lerch +33 more
TL;DR: MRI-based phenotyping identified previously unknown connections between Nrxn1α, En2 and Fmr1; Nlgn3, BTBR and Slc6A4; and also between X monosomy and Mecp2, which can be linked to the under and over-connectivity found in autism.
Journal ArticleDOI
Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses
Spencer C. Maughan,M. Pasternak,Narelle Cairns,Guy Kiddle,Thorsten Brach,Renee S Jarvis,Florian H. Haas,Jeroen Nieuwland,Benson Lim,Christopher L. Muller,Enrique Salcedo-Sora,Cordula Kruse,Mathilde Orsel,Rüdiger Hell,Anthony J. Miller,Patrick G. Bray,Christine H. Foyer,James A. H. Murray,Andreas J. Meyer,Christopher S. Cobbett +19 more
TL;DR: It is concluded that a family of three plastid thiol transporters homologous to the Plasmodium falciparum chloroquine-resistance transporter, PfCRT play a significant role in regulating GSH levels and the redox potential of the cytosol.
Journal ArticleDOI
Absence of Preference for Social Novelty and Increased Grooming in Integrin β3 Knockout Mice: Initial Studies and Future Directions
Michelle D. Carter,Charisma R. Shah,Christopher L. Muller,Jacqueline N. Crawley,Ana Carneiro,Jeremy Veenstra-VanderWeele +5 more
TL;DR: Preliminary studies reveal altered social and repetitive behavior in these mice, which suggests that the integrin β3 subunit may be involved in brain systems relevant to ASD.