C
Christine Laclef
Researcher at University of Paris
Publications - 24
Citations - 2619
Christine Laclef is an academic researcher from University of Paris. The author has contributed to research in topics: Cilium & Ciliopathy. The author has an hindex of 16, co-authored 24 publications receiving 2430 citations. Previous affiliations of Christine Laclef include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Journal ArticleDOI
The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome
Marion Delous,Lekbir Baala,Rémi Salomon,Christine Laclef,Christine Laclef,Jeanette Vierkotten,Kálmán Tory,Christelle Golzio,Tiphanie Lacoste,Laurianne Besse,Laurianne Besse,Catherine Ozilou,Imane Moutkine,Nathan E. Hellman,Isabelle Anselme,Isabelle Anselme,Flora Silbermann,Christine Vesque,Christine Vesque,Christoph Gerhardt,Eleanor Rattenberry,Matthias T.F. Wolf,Marie Claire Gubler,Jelena Martinovic,Férechté Encha-Razavi,Nathalie Boddaert,Marie Gonzales,Marie Alice Macher,Hubert Nivet,Gérard Champion,Jean Pierre Berthélémé,Patrick Niaudet,Fiona McDonald,Friedhelm Hildebrandt,Colin A. Johnson,Michel Vekemans,Corinne Antignac,Ulrich Rüther,Sylvie Schneider-Maunoury,Sylvie Schneider-Maunoury,Tania Attié-Bitach,Sophie Saunier +41 more
TL;DR: Findings show that mutations in RPGRIP1L can cause the multiorgan phenotypic abnormalities found in CORS or MKS, which therefore represent a continuum of the same underlying disorder.
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Six1 is required for the early organogenesis of mammalian kidney.
TL;DR: The results show that Eya1 and Six1 genetically interact during mammalian kidney development, because most compound heterozygous embryos show hypoplastic kidneys and establish a role for Six1 in the initial inductive step for metanephric development.
Journal ArticleDOI
Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool.
Nathalie Spassky,Young-Goo Han,Andrea Aguilar,Laetitia Strehl,L. Besse,Christine Laclef,M. Romaguera Ros,José Manuel García-Verdugo,Arturo Alvarez-Buylla +8 more
TL;DR: This work shows that Kif3a is essential for Shh-dependent expansion of cerebellar progenitors and Dysfunctional cilia are associated with diverse human disorders including Bardet-Biedl and Joubert syndromes.
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Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid
TL;DR: The results indicate that Eya1 controls critical early inductive events involved in the morphogenesis of thymus, parathyroid and thyroid.
Journal ArticleDOI
Altered myogenesis in Six1-deficient mice
Christine Laclef,Ghislaine Hamard,Josiane Demignon,Evelyne Souil,Christophe Houbron,Pascal Maire +5 more
TL;DR: It appears that Six1 plays a specific role in Hypaxial muscle differentiation, distinct from those of other hypaxial determinants such as Pax3, cMet, Lbx1 or Mox2.