I
Imane Moutkine
Researcher at French Institute of Health and Medical Research
Publications - 22
Citations - 1279
Imane Moutkine is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Receptor & Serotonin. The author has an hindex of 11, co-authored 16 publications receiving 1094 citations. Previous affiliations of Imane Moutkine include Pierre-and-Marie-Curie University & University of Paris.
Papers
More filters
Journal ArticleDOI
The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome
Marion Delous,Lekbir Baala,Rémi Salomon,Christine Laclef,Christine Laclef,Jeanette Vierkotten,Kálmán Tory,Christelle Golzio,Tiphanie Lacoste,Laurianne Besse,Laurianne Besse,Catherine Ozilou,Imane Moutkine,Nathan E. Hellman,Isabelle Anselme,Isabelle Anselme,Flora Silbermann,Christine Vesque,Christine Vesque,Christoph Gerhardt,Eleanor Rattenberry,Matthias T.F. Wolf,Marie Claire Gubler,Jelena Martinovic,Férechté Encha-Razavi,Nathalie Boddaert,Marie Gonzales,Marie Alice Macher,Hubert Nivet,Gérard Champion,Jean Pierre Berthélémé,Patrick Niaudet,Fiona McDonald,Friedhelm Hildebrandt,Colin A. Johnson,Michel Vekemans,Corinne Antignac,Ulrich Rüther,Sylvie Schneider-Maunoury,Sylvie Schneider-Maunoury,Tania Attié-Bitach,Sophie Saunier +41 more
TL;DR: Findings show that mutations in RPGRIP1L can cause the multiorgan phenotypic abnormalities found in CORS or MKS, which therefore represent a continuum of the same underlying disorder.
Journal ArticleDOI
5-HT 2B receptors are required for serotonin-selective antidepressant actions
Silvina L. Diaz,Stéphane Doly,Stéphane Doly,Nicolas Narboux-Nême,Nicolas Narboux-Nême,Sebastian P. Fernandez,Sebastian P. Fernandez,P. Mazot,P. Mazot,Sophie Marie Banas,Sophie Marie Banas,Katia Boutourlinsky,Katia Boutourlinsky,Imane Moutkine,Imane Moutkine,Arnauld Belmer,Arnauld Belmer,Anne Roumier,Anne Roumier,Luc Maroteaux,Luc Maroteaux +20 more
TL;DR: The 5-HT2B receptor appears to positively modulate serotonergic activity and to be required for the therapeutic actions of SSRIs, and should be considered as a new tractable target in the combat against depression.
5-HT(2B) receptors are required for serotonin-selective antidepressant actions
Silvina L. Diaz,Stéphane Doly,Stéphane Doly,Nicolas Narboux-Nême,Nicolas Narboux-Nême,Sebastian P. Fernandez,Sebastian P. Fernandez,P. Mazot,P. Mazot,Sophie Marie Banas,Sophie Marie Banas,Katia Boutourlinsky,Katia Boutourlinsky,Imane Moutkine,Imane Moutkine,Arnauld Belmer,Arnauld Belmer,Anne Roumier,Anne Roumier,Luc Maroteaux,Luc Maroteaux +20 more
TL;DR: The 5-HT(2B) receptor appears to positively modulate serotonergic activity and to be required for the therapeutic actions of SSRIs in the combat against depression as mentioned in this paper.
Journal ArticleDOI
Plasma membrane targeting of podocin through the classical exocytic pathway: effect of NPHS2 mutations.
TL;DR: The data suggest that most of NPHS2 mutations lead to retention of podocin in the endoplasmic reticulum and therefore provide a rationale for devising therapeutic approaches aimed at correcting the protein processing defect.
Journal ArticleDOI
GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase.
Martin Heubl,Martin Heubl,Jinwei Zhang,Jinwei Zhang,Jinwei Zhang,Jessica C. Pressey,Jessica C. Pressey,Sana Al Awabdh,Sana Al Awabdh,Marianne Renner,Marianne Renner,Ferran Gomez-Castro,Ferran Gomez-Castro,Imane Moutkine,Imane Moutkine,Emmanuel Eugène,Emmanuel Eugène,Marion Russeau,Marion Russeau,Kristopher T. Kahle,Jean Christophe Poncer,Jean Christophe Poncer,Sabine Lévi,Sabine Lévi +23 more
TL;DR: It is demonstrated that inhibitory transmission, via GABAA receptor and WNK signaling, regulates KCC2 expression in the membrane of hippocampal neurons.