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Christoph Thiele
Researcher at University of Bonn
Publications - 64
Citations - 10767
Christoph Thiele is an academic researcher from University of Bonn. The author has contributed to research in topics: Lipid droplet & Membrane protein. The author has an hindex of 44, co-authored 60 publications receiving 9875 citations. Previous affiliations of Christoph Thiele include Heidelberg University & Max Planck Society.
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Journal ArticleDOI
Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts
TL;DR: It is demonstrated that lipid rafts are critically involved in regulating Aβ generation and the existence of two APP pools is suggested, although APP inside raft clusters seems to be cleaved by β-secretase, APP outside rafts undergoes cleavage by α- secretase.
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Lipoprotein particles are required for Hedgehog and Wingless signalling
TL;DR: It is shown that Wingless, Hedgehog and glycophosphatidylinositol-linked proteins copurify with lipoprotein particles, and co-localize with them in the developing wing epithelium of Drosophila.
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SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocytosis
Thorsten Lang,Dieter Bruns,Dirk Wenzel,Dietmar Riedel,Phillip Holroyd,Christoph Thiele,Reinhard Jahn +6 more
TL;DR: In the plasmalemma, syntaxins are concentrated in 200 nm large, cholesterol‐dependent clusters at which secretory vesicles preferentially dock and fuse, which suggests that high local concentrations of SNAREs are required for efficient fusion.
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Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles
Christoph Thiele,Christoph Thiele,Matthew J. Hannah,Matthew J. Hannah,Matthew J. Hannah,Falk Fahrenholz,Wieland B. Huttner,Wieland B. Huttner +7 more
TL;DR: It is proposed that specific interactions between cholesterol and SLMV membrane proteins, such as synaptophysin, contribute to both the segregation of SLMv membrane constituents from plasma-membrane constituents, and the induction of synaptic-vesicle curvature.
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Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid
Anne A. Schmidt,Anne A. Schmidt,Michael Wolde,Christoph Thiele,Christoph Thiele,Werner Fest,Hartmut Kratzin,Alexandre V. Podtelejnikov,Walter Witke,Wieland B. Huttner,Wieland B. Huttner,Hans-Dieter Söling +11 more
TL;DR: It is shown that endophilin I is essential for the formation of synaptic-like microvesicles (SLMVs) from the plasma membrane and proposed that, through this action, endophILin I works with dynamin to mediate synaptic vesicle invagination from the Plasma membrane and fission.