C
Christophe Caux
Researcher at French Institute of Health and Medical Research
Publications - 254
Citations - 32907
Christophe Caux is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Immune system & Dendritic cell. The author has an hindex of 74, co-authored 232 publications receiving 30760 citations. Previous affiliations of Christophe Caux include Centre national de la recherche scientifique & International Facility Management Association.
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Methods for treating cancer using a combination of a tumor-derived dendritic cell inhibitory factor antagonist and a toll-like receptor agonist
Christophe Caux,Alain Vicari +1 more
TL;DR: In this article, materials and methods are provided for treating disease states, including cancer, by activating dendritic cells from the host which are rendered hypo-responsive to activation stimuli by the disease.
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In Vitro and In Vivo Comparison of Lymphocytes Transduced with a Human CD16 or with a Chimeric Antigen Receptor Reveals Potential Off-Target Interactions due to the IgG2 CH2-CH3 CAR-Spacer
Béatrice Clémenceau,Sandrine Valsesia-Wittmann,Anne-Catherine Jallas,Régine Vivien,Raphael Rousseau,Aurélien Marabelle,Christophe Caux,Henri Vié +7 more
TL;DR: Analysis of the in vivo xenogeneic system suggested that the human CH2-CH3 IgG2 used as a spacer in the authors' construct was able to interact with the FcR present at the cell surface of the few NSG-FcR+ remaining immune cells, leading to blockage of the NK-92CAR in the periphery of the engrafted tumor cells, stresses the critical role of the composition of the spacer domain.
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The Class 6 Semaphorin SEMA6A Is Induced by Interferon-γ and Defines an Activation Status of Langerhans Cells Observed in Pathological Situations
Gregory Gautier,Blandine de Saint-Vis,Brigitte Senechal,Jean-Jacques Pin,Elizabeth E. M. Bates,Christophe Caux,Frederic Geissmann,Pierre Garrone +7 more
TL;DR: The expression of SEMA6A, for which the ligand and function remain unknown, may identify an alternative IFN-gamma-dependent activation status of LCs in vivo.
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Recruitment and Expansion of Tregs Cells in the Tumor Environment—How to Target Them?
Justine Cinier,Margaux Hubert,Laurie Besson,Anthony Di Roio,Céline Rodriguez,Vincent Lombardi,Christophe Caux,Christine Ménétrier-Caux +7 more
TL;DR: In this paper, the authors investigated the mechanisms involved in the recruitment, amplification and stability of Tregs in the tumor microenvironment (TME) and reviewed the strategies currently developed to inhibit Treg's deleterious impact in the TME by either inhibiting their recruitment, blocking their expansion, favoring their plastic transformation into other CD4+ T-cell subsets, or depleting them specifically in the tissue periphery and normal tissues.
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A novel combination of chemotherapy and immunotherapy controls tumor growth in mice with a human immune system.
Aude Burlion,Rodrigo Nalio Ramos,Pukar Kc,Kelhia Sendeyo,Aurélien Corneau,Christine Ménétrier-Caux,Eliane Piaggio,Daniel Olive,Christophe Caux,Gilles Marodon +9 more
TL;DR: The results indicate that a combination of anti-ICOS mAb and chemotherapy controls tumor growth in humanized mice, opening new perspectives for the treatment of breast cancer.