C
Christophe Caux
Researcher at French Institute of Health and Medical Research
Publications - 254
Citations - 32907
Christophe Caux is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Immune system & Dendritic cell. The author has an hindex of 74, co-authored 232 publications receiving 30760 citations. Previous affiliations of Christophe Caux include Centre national de la recherche scientifique & International Facility Management Association.
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Journal ArticleDOI
A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.
Gregory Gautier,Martine Humbert,Florence Deauvieau,Mathieu Scuiller,John Hiscott,Elizabeth E. M. Bates,Giorgio Trinchieri,Christophe Caux,Pierre Garrone +8 more
TL;DR: Analysis of interferon regulatory factors (IRF) regulation in moDC suggests a role for IRF7/8 in mediating IRF3-independent type I IFN and possibly IL-12p35 synthesis in response to TLR7/9 and R-848/Resiquimod synergized with poly(I:C) (TLR3 ligand) or lipopolysaccharide (LPS; TLR4 ligand).
Journal ArticleDOI
CD34+ Hematopoietic Progenitors From Human Cord Blood Differentiate Along Two Independent Dendritic Cell Pathways in Response to Granulocyte-Macrophage Colony-Stimulating Factor Plus Tumor Necrosis Factor α: II. Functional Analysis
Christophe Caux,Catherine Massacrier,Béatrice Vanbervliet,Bertrand Dubois,Isabelle Durand,Marina Cella,Antonio Lanzavecchia,J Banchereau +7 more
TL;DR: Results show that different pathways of DC development might exist in vivo: (1) the LC type, which might be mainly involved in cellular immune responses, and (2) the CD14-derived DC related to dermal DCs or circulating blood DCs, which could be involved in humoral immune responses.
Journal Article
The Cytokine Profile Expressed by Human Dendritic Cells Is Dependent on Cell Subtype and Mode of Activation
de Saint-Vis B,Fugier-Vivier I,Catherine Massacrier,Claude Gaillard,Béatrice Vanbervliet,Smina Ait-Yahia,J Banchereau,Yong-Jun Liu,Serge Lebecque,Christophe Caux +9 more
TL;DR: The pattern of cytokines expressed by two independent dendritic cell (DC) subpopulations generated in vitro from human cord blood CD34+ progenitors cultured with granulocyte-macrophage CSF and TNF-alpha seemed more closely related to germinal center d endritic cellsGCDC than to Langerhans cells.
Journal ArticleDOI
TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway
Sébastien Viel,Antoine Marçais,Fernando Souza Fonseca Guimaraes,Fernando Souza Fonseca Guimaraes,Róisín M. Loftus,Jessica Rabilloud,Morgan Grau,Sophie Degouve,Sophia Djebali,Amélien Sanlaville,Emily Charrier,Jacques Bienvenu,Julien C. Marie,Julien C. Marie,Christophe Caux,Jacqueline Marvel,Liam Town,Nicholas D. Huntington,Laurent Bartholin,David K. Finlay,Mark J. Smyth,Mark J. Smyth,Thierry Walzer +22 more
TL;DR: The results suggest that boosting the metabolic activity of antitumor lymphocytes could be an effective strategy to promote immune-mediated tumor suppression and provide genetic, pharmacologic, and biochemical evidence that the kinase mTOR is a crucial signaling integrator of pro- and anti-inflammatory cytokines in NK cells.
Journal ArticleDOI
Macrophage Inflammatory Protein 3α Is Expressed at Inflamed Epithelial Surfaces and Is the Most Potent Chemokine Known in Attracting Langerhans Cell Precursors
Marie-Caroline Dieu-Nosjean,Catherine Massacrier,Bernhard Homey,Béatrice Vanbervliet,Jean-Jacques Pin,Alain Vicari,Serge Lebecque,Colette Dezutter-Dambuyant,Daniel Schmitt,Albert Zlotnik,Christophe Caux +10 more
TL;DR: Observations suggest that macrophage inflammatory protein (MIP)-3α plays a central role in LC precursor recruitment into the epithelium during inflammation, and might open new ways to control epithelial immunity.