C
Christophe Caux
Researcher at French Institute of Health and Medical Research
Publications - 254
Citations - 32907
Christophe Caux is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Immune system & Dendritic cell. The author has an hindex of 74, co-authored 232 publications receiving 30760 citations. Previous affiliations of Christophe Caux include Centre national de la recherche scientifique & International Facility Management Association.
Papers
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Book ChapterDOI
Functional CD40 Antigen on B Cells, Dendritic Cells and Fibroblasts
Jacques Banchereau,Bertrand Dubois,Jérôme Fayette,N Burdin,Francine Brière,P Miossec,Marie-Clotilde Rissoan,C. van Kooten,Christophe Caux +8 more
TL;DR: During antigen specific immune responses, antigen specific naive B cells undergo a cascade of events including activation, expansion, mutations, isotype switch, selections and differentiation into either antibody secreting plasma cells or memory B cells.
Journal ArticleDOI
Pharmacological analysis of calcium responses mediated by the human A3 adenosine receptor in monocyte-derived dendritic cells and recombinant cells.
James Fossetta,James O. Jackson,Gregory Deno,Xuedong Fan,Xixuan Karen Du,Loretta A. Bober,Anne Soudé-Bermejo,Odette de Bouteiller,Christophe Caux,Charles A. Lunn,Daniel Lundell,R. Kyle Palmer +11 more
TL;DR: The results provide an extensive analysis of A3-mediated calcium signaling and unequivocally identify immature MDDCs as native expressers of the human A3 receptor.
Journal ArticleDOI
Follicular B lymphomas generate regulatory T cells via the ICOS/ICOSL pathway and are susceptible to treatment by anti-ICOS/ICOSL therapy
Kieu-Suong Le,Marie-Laure Thibult,Sylvaine Just-Landi,Sonia Pastor,Françoise Gondois-Rey,Samuel Granjeaud,Florence Broussais,Reda Bouabdallah,Renaud Colisson,Christophe Caux,Christine Ménétrier-Caux,Dominique Leroux,Luc Xerri,Daniel Olive,Daniel Olive +14 more
TL;DR: It is suggested that targeting the ICOS/ICOSL pathway may be a promising immunotherapy for FL treatment and a key role for Tregs in FL pathogenesis is highlighted.
Patent
Chemokines as adjuvants of immune response
Christophe Caux,Béatrice Vanbervliet,Carine Paturel,Alain Vicari,Giorgio Trinchieri,Francine Brière,Nathalie Bendriss +6 more
TL;DR: In this article, materials and methods for treating disease states, including cancer, infectious diseases, autoimmune diseases, transplantation, and allergy by facilitating or inhibiting the migration or activation of a specific subset of antigen-presenting dendritic cells known as plasmacytoid dendocyte cells (pDC) are provided.
Journal ArticleDOI
A novel regulation of PD-1 ligands on mesenchymal stromal cells through MMP-mediated proteolytic cleavage
Colette Dezutter-Dambuyant,Isabelle Durand,Laurent Alberti,Nathalie Bendriss-Vermare,Jenny Valladeau-Guilemond,Adeline Duc,Audrey Magron,Anne-Pierre Morel,Vanja Sisirak,Céline Rodriguez,David G. Cox,Daniel Olive,Christophe Caux +12 more
TL;DR: It is demonstrated that foreskin fibroblasts (FFs) potently inhibit CD3+ T cell proliferation through a mechanism involving early apoptosis of activated T cells, and suggested that MMP-dependent cleavage of PD-1 ligands on fibro Blasts may limit their immunosuppressive capacity and thus contribute to the exacerbation of inflammation in tissues.