C
Christophe Caux
Researcher at French Institute of Health and Medical Research
Publications - 254
Citations - 32907
Christophe Caux is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Immune system & Dendritic cell. The author has an hindex of 74, co-authored 232 publications receiving 30760 citations. Previous affiliations of Christophe Caux include Centre national de la recherche scientifique & International Facility Management Association.
Papers
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Journal ArticleDOI
Human Langerhans Cells Express a Specific TLR Profile and Differentially Respond to Viruses and Gram-Positive Bacteria
Vincent Flacher,Marielle Bouschbacher,Estelle Verronese,Catherine Massacrier,Vanja Sisirak,Odile Berthier-Vergnes,Blandine de Saint-Vis,Christophe Caux,Colette Dezutter-Dambuyant,Serge Lebecque,Jenny Valladeau +10 more
TL;DR: Human LC are equipped with TLR that enable direct detection of PAMP from viruses and Gram-positive bacteria, subsequent phenotypic maturation, and differential cytokine production, which implies a significant role for LC in the control of skin immune responses.
Journal ArticleDOI
Human dendritic cells skew isotype switching of cd40-activated naive b cells towards iga1 and iga2
Jérôme Fayette,Bertrand Dubois,Stéphane Vandenabeele,J M Bridon,Béatrice Vanbervliet,Isabelle Durand,Jacques Banchereau,Christophe Caux,Francine Brière +8 more
TL;DR: Results suggest that in addition to activating T cells in the extrafollicular areas of secondary lymphoid organs, human D-Lc also directly modulate T cell–dependent B cell growth and differentiation, by inducing the IgA isotype switch.
Journal Article
Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes.
Bertrand Dubois,Catherine Massacrier,Béatrice Vanbervliet,Jérôme Fayette,Francine Brière,Jacques Banchereau,Christophe Caux +6 more
TL;DR: IL-12 is identified as the mandatory molecule secreted by CD40-activated DC that promote the differentiation of naive B cells into plasma cells secreting high levels of IgM, demonstrating that the role of DC in humoral responses is not confined to the activation of T cells and extending the physiologic relevance of DC/B cell interaction.
Journal ArticleDOI
Tumour escape from immune surveillance through dendritic cell inactivation
TL;DR: The current knowledge of the physiopathology of DC in cancer is reviewed, which paves the way for novel strategies of therapeutic intervention.
Book ChapterDOI
CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha.
Christophe Caux,Catherine Massacrier,Béatrice Vanbervliet,Bertrand Dubois,de Saint-Vis B,Colette Dezutter-Dambuyant,Christelle Jacquet,Daniel Schmitt,Jacques Banchereau +8 more