C
Christophe Caux
Researcher at French Institute of Health and Medical Research
Publications - 254
Citations - 32907
Christophe Caux is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Immune system & Dendritic cell. The author has an hindex of 74, co-authored 232 publications receiving 30760 citations. Previous affiliations of Christophe Caux include Centre national de la recherche scientifique & International Facility Management Association.
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Journal ArticleDOI
Expression and factor-dependent modulation of the interleukin-3 receptor subunits on human hematopoietic cells
Noriko Sato,Christophe Caux,Toshio Kitamura,Yoshinari Watanabe,Ken-ichi Arai,Jacques Banchereau,Atsushi Miyajima +6 more
TL;DR: Different cytokines appear to have different mechanisms for enhancement of IL-3-dependent proliferation, and this enhancement could be correlated with upregulation of the IL- 3R expression is examined.
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Differences in tumor regulatory T-cell localization and activation status impact patient outcome.
TL;DR: Evidence in breast carcinoma that Treg localized within lymphoid aggregates, but not in the tumor bed, have a negative impact on patients' survival is obtained and selective Treg recruitment through CCR4/CCL22 in the lymphoid aggregation upon contact with dendritic cells is shown.
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Impaired Toll-like receptor 7 and 9 signaling: from chronic viral infections to cancer.
TL;DR: The limited responsiveness of pDCs might contribute to reduced innate immune responses during chronic viral infections and oncogenesis, and represent a target for new therapeutic approaches based on TLR agonists.
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Targeting pattern recognition receptors in cancer immunotherapy
TL;DR: This review discusses the balance between the intrinsic activation of PRR in tumor cells and the extrinsic microenvironment activation in term of overall effect ofPRR ligands on tumor development and reviews recent advances in the field.
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Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells
Beatris Mastelic-Gavillet,Blanca Navarro Rodrigo,Laure Décombaz,Haiping Wang,Giuseppe Ercolano,Rita Ahmed,Leyder Elena Lozano,Angela Ianaro,Laurent Derré,Massimo Valerio,Thomas Tawadros,Patrice Jichlinski,Tu Nguyen-Ngoc,Daniel E. Speiser,Grégory Verdeil,Nicolas Gestermann,Olivier Dormond,Lana E. Kandalaft,George Coukos,Camilla Jandus,Christine Ménétrier-Caux,Christine Ménétrier-Caux,Christophe Caux,Christophe Caux,Ping-Chih Ho,Pedro Romero,Alexandre Harari,Selena Vigano +27 more
TL;DR: A2AR/PKA/mTORC1 is unveiled as the main Ado signaling pathway impairing the immune competence of peripheral T cells and TILs and reinforces the importance of the adenosinergic pathway as a target for next-generation immunotherapy.