C
Christopher Calabrese
Researcher at St. Jude Children's Research Hospital
Publications - 28
Citations - 4405
Christopher Calabrese is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Medulloblastoma & Metastasis. The author has an hindex of 19, co-authored 28 publications receiving 4051 citations. Previous affiliations of Christopher Calabrese include University of Minnesota.
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Journal ArticleDOI
A Perivascular Niche for Brain Tumor Stem Cells
Christopher Calabrese,Helen Poppleton,Mehmet Kocak,Twala L. Hogg,Christine E. Fuller,Blair Hamner,Eun Young Oh,M. Waleed Gaber,David Finklestein,Meredith Allen,Adrian J. Frank,Ildar T. Bayazitov,Stanislav S. Zakharenko,Amar Gajjar,Andrew M. Davidoff,Richard J. Gilbertson +15 more
TL;DR: This work shows that endothelial cells interact closely with self-renewing brain tumor cells and secrete factors that maintain these cells in a stem cell-like state, and proposes that brain CSCs are maintained within vascular niches that are important targets for therapeutic approaches.
Journal ArticleDOI
Radial glia cells are candidate stem cells of ependymoma
Michael D. Taylor,Helen Poppleton,Christine E. Fuller,Xiaoping Su,Yongxing Liu,Patricia Jensen,Susan Magdaleno,James Dalton,Christopher Calabrese,Julian Board,Tobey J. MacDonald,Jim Rutka,Abhijit Guha,Amar Gajjar,Tom Curran,Richard J. Gilbertson +15 more
TL;DR: It is reported that histologically identical, but genetically distinct, ependymomas exhibit patterns of gene expression that recapitulate those of radial glia cells in the corresponding region of the central nervous system.
Journal ArticleDOI
Dietary modulation of the microbiome affects autoinflammatory disease
John R. Lukens,Prajwal Gurung,Peter Vogel,Gordon R. Johnson,Robert A. Carter,Daniel J. McGoldrick,Srinivasa Rao Bandi,Christopher Calabrese,Lieselotte Vande Walle,Mohamed Lamkanfi,Thirumala-Devi Kanneganti +10 more
TL;DR: Diet-associated changes in the intestinal microbiome is revealed as a crucial factor regulating inflammasome- and caspase-8-mediated maturation of IL-1β and osteomyelitis in Pstpip2cmo mice.
Journal ArticleDOI
The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation
Tamar Uziel,Frederique Zindy,Suqing Xie,Youngsoo Lee,Antoine Forget,Susan Magdaleno,Jerold E. Rehg,Christopher Calabrese,David J. Solecki,Charles G. Eberhart,Sarah E. Sherr,Sarah Plimmer,Steven C. Clifford,Mary E. Hatten,Peter J. McKinnon,Richard J. Gilbertson,Tom Curran,Charles J. Sherr,Martine F. Roussel +18 more
TL;DR: In this paper, the cyclin-dependent kinase inhibitor p18(Ink4c) is transiently expressed in mouse cerebellar granule neuronal precursor cells as they exit the cell division cycle and differentiate.
Journal Article
ERBB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma.
Roberto Hernan,Rami Fasheh,Christopher Calabrese,Adrian J. Frank,Kirsteen H. Maclean,David Allard,Roger Barraclough,Richard J. Gilbertson +7 more
TL;DR: It is demonstrated that ER BB2 overexpression increases the migration of medulloblastoma cells across basement membranes in vitro and an ERBB2 driven prometastatic pathway that may provide a novel target for therapeutic intervention in metastatic medullOBlastoma is identified.