Twala L. Hogg

TL;DR: This work shows that endothelial cells interact closely with self-renewing brain tumor cells and secrete factors that maintain these cells in a stem cell-like state, and proposes that brain CSCs are maintained within vascular niches that are important targets for therapeutic approaches.

TL;DR: Evidence is provided that a discrete subtype of medulloblastoma that contains activating mutations in the WNT pathway effector CTNNB1 (hereafter, WNT subtype) arises outside the cerebellum from cells of the dorsal brainstem, the first evidence, to the authors' knowledge, that subtypes of medULLoblastomas have distinct cellular origins.

TL;DR: Genome-wide expression profiles can partition large tumor cohorts into subgroups that are enriched for specific genetic alterations that may assist ultimately in the selection of patients for future clinical trials of molecular targeted therapies.

TL;DR: Comparison of matched mouse and human tumours revealed selective deregulation in the expression and copy number of genes that control synaptogenesis, pinpointing disruption of this pathway as a critical event in the production of this ependymoma subgroup.

TL;DR: The data demonstrate that a diverse repertoire of TCR is able to recognize a single MHC class I epitope and that mice make use of this potential diversity in the primary response to a natural viral infection.