Daniel J. McGoldrick

TL;DR: The mutational spectrum is similar to myeloid tumours, and moreover, the global transcriptional profile of ETP ALL was similar to that of normal andMyeloid leukaemia haematopoietic stem cells, suggesting that addition of myeloids-directed therapies might improve the poor outcome of E TP ALL.

TL;DR: Diet-associated changes in the intestinal microbiome is revealed as a crucial factor regulating inflammasome- and caspase-8-mediated maturation of IL-1β and osteomyelitis in Pstpip2cmo mice.

TL;DR: It is found that Aim2-deficient mice were hypersusceptible to colonic tumor development and a synergy between a specific host genetic factor and gut microbiota in determining the susceptibility to colorectal cancer is uncovered.

TL;DR: The application of whole-genome transcriptional sequencing to systematically identify the sRNAs of Streptococcus pneumoniae is described and it is demonstrated that many of the identified s RNAs have important global and niche-specific roles in virulence.

TL;DR: A transplant-based screen to identify regulators of HSPC engraftment and report that Foxa3 is critical for optimal HSC function after transplant is performed.