K
Kirsteen H. Maclean
Researcher at St. Jude Children's Research Hospital
Publications - 32
Citations - 3863
Kirsteen H. Maclean is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Apoptosis & Tumor microenvironment. The author has an hindex of 19, co-authored 26 publications receiving 3627 citations. Previous affiliations of Kirsteen H. Maclean include University College London.
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Journal ArticleDOI
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
John R. Jeffers,Evan Parganas,Evan Parganas,Youngsoo Lee,Chunying Yang,Jinling Wang,Jennifer Brennan,Kirsteen H. Maclean,Jia-wen Han,Thomas Chittenden,James N. Ihle,James N. Ihle,Peter J. McKinnon,John L. Cleveland,Gerard P. Zambetti +14 more
TL;DR: It is reported that Puma is essential for hematopoietic cell death triggered by ionizing radiation, deregulated c-Myc expression, and cytokine withdrawal, and required for IR-induced death throughout the developing nervous system and accounts for nearly all of the apoptotic activity attributed to p53 under these conditions.
Journal ArticleDOI
ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
Angela Alexander,Sheng Li Cai,Jinhee Kim,Adrian Nanez,Mustafa Sahin,Kirsteen H. Maclean,Ken Inoki,Kun-Liang Guan,Jianjun Shen,Maria D. Person,Donna F. Kusewitt,Donna F. Kusewitt,Gordon B. Mills,Michael B. Kastan,Cheryl L. Walker,Cheryl L. Walker +15 more
TL;DR: A cytoplasmic pathway for ROS-induced ATM activation of TSC2 to regulate mTORC1 signaling and autophagy is identified, identifying an integration node for the cellular damage response with key pathways involved in metabolism, protein synthesis, and cell survival.
Journal ArticleDOI
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression
Troy A. Baudino,Catriona McKay,Helene Pendeville-Samain,Jonas Nilsson,Kirsteen H. Maclean,Elsie White,Ann C. Davis,James N. Ihle,John L. Cleveland +8 more
TL;DR: Findings support the model wherein c-Myc promotes cell growth and transformation, as well as vascular and hematopoietic development, by functioning as a master regulator of angiogenic factors.
Journal ArticleDOI
Mitochondrial dysfunction in ataxia-telangiectasia.
Yasmine A. Valentin-Vega,Kirsteen H. Maclean,Jacqueline Tait-Mulder,Sandra Milasta,Meredith A. Steeves,Frank C. Dorsey,John L. Cleveland,Douglas R. Green,Michael B. Kastan +8 more
TL;DR: A model in which ATM plays direct roles in modulating mitochondrial homeostasis is supported and it is suggested that mitochondrial dysfunction and associated increases in mitochondrial reactive oxygen species contribute to the cancer-prone phenotype observed in organisms lacking ATM.
Journal ArticleDOI
Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis
TL;DR: It is demonstrated that intermittent chloroquine use effectively prevents cancer in mouse models of 2 genetically distinct human cancer syndromes, Burkitt lymphoma and ataxia telangiectasia, suggesting that agents targeting lysosome-mediated degradation may be effective in cancer prevention.