Christopher Chiu

TL;DR: Transient depletion of neutrophils significantly suppressed VEGF:VEGF-receptor association, a signature of MMP-9 activity, and markedly reduced the frequency of initial angiogenic switching in dysplasias, suggesting infiltrating neutrophil can play a crucial role in activating angiogenesis in a previously quiescent tissue vasculature during the early stages of carcinogenesis.

TL;DR: B-cell responses in 24 healthy adults immunized with the inactivated 2009 pandemic H1N1 vaccine in 2009 found a rapid, predominantly IgG-producing vaccine-specific plasmablast response, which indicates that antibodies capable of neutralizing most influenza subtypes might indeed be elicited by vaccination.

TL;DR: The first SARS-CoV-2 human challenge study in young adults was presented in this paper , where 36 healthy adults were intranasally inoculated with a wild-type virus (SARS-coV-1/human/GBR/484861/2020) intranascally in an open-label, non-randomized study.

TL;DR: It is found that CD8+ Trm cells in the human lung can confer protection against severe respiratory viral disease when humoral immunity is overcome, implying that the immunodominance hierarchy can be defined.

TL;DR: This study shows that annual influenza vaccines induce antibody responses that are largely directed against the highly variable HA head region, and provides a potential vaccination strategy where heterologous influenza immunization could be used for increasing the levels of broadly neutralizing antibodies and for priming the human population to respond quickly to emerging pandemic influenza threats.