Jane-Hwei Lee

TL;DR: Although scarce after annual influenza vaccination, B cells producing antibodies capable of neutralizing multiple influenza strains are abundant in humans infected with pandemic 2009 H1N1 influenza.

TL;DR: B-cell responses in 24 healthy adults immunized with the inactivated 2009 pandemic H1N1 vaccine in 2009 found a rapid, predominantly IgG-producing vaccine-specific plasmablast response, which indicates that antibodies capable of neutralizing most influenza subtypes might indeed be elicited by vaccination.

TL;DR: An in-depth study of the B cell response to the pandemic 2009 H1N1 vaccine over consecutive years found that people with low titers of preexisting antibodies were more likely to generate a broadly reactive response that targets the more conserved hemagglutinin (HA) stalk region, whereas those with higher levels of preeXisting antibodies responded by targeting the more variable HA head.

TL;DR: It is found that TG2-specific plasma cells are markedly expanded within the duodenal mucosa in individuals with active celiac disease, demonstrating that there is a germline repertoire with high affinity for TG2 that may favor massive generation of autoreactive B cells.

TL;DR: One of the stalk-specific MAbs was subtype cross-reactive to H1 and H2 hemagglutinins, suggesting a role for stalk- specific antibodies in protection against influenza illness, especially by a novel viral subtype which can cause pandemics.