M
Mark H. Almond
Researcher at Imperial College London
Publications - 14
Citations - 474
Mark H. Almond is an academic researcher from Imperial College London. The author has contributed to research in topics: Cytotoxic T cell & Viral load. The author has an hindex of 8, co-authored 14 publications receiving 368 citations. Previous affiliations of Mark H. Almond include National Institutes of Health & Johns Hopkins University.
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Journal ArticleDOI
RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection
Agnieszka Jozwik,Maximillian S. Habibi,Allan Paras,Jie Zhu,Aleks Guvenel,Jaideep Dhariwal,Mark H. Almond,Ernie Wong,Annemarie Sykes,Matthew Maybeno,Jerico Del Rosario,Maria Belen Trujillo-Torralbo,Patrick Mallia,John Sidney,Bjoern Peters,Onn Min Kon,Alessandro Sette,Sebastian L. Johnston,Peter J. M. Openshaw,Christopher Chiu +19 more
TL;DR: It is found that CD8+ Trm cells in the human lung can confer protection against severe respiratory viral disease when humoral immunity is overcome, implying that the immunodominance hierarchy can be defined.
Journal ArticleDOI
Obesity and susceptibility to severe outcomes following respiratory viral infection.
Mark H. Almond,Michael R. Edwards,Michael R. Edwards,Wendy S. Barclay,Sebastian L. Johnston,Sebastian L. Johnston +5 more
TL;DR: A brief synthesis of the recent advances in the understanding of the immunomodulatory effects of obesity on outcomes following respiratory viral infection, with a particular focus on pandemic influenza is presented.
Journal ArticleDOI
Addressing unmet needs in understanding asthma mechanisms: From the European Asthma Research and Innovation Partnership (EARIP) Work Package (WP)2 collaborators
Michael R. Edwards,Sejal Saglani,Jürgen Schwarze,Chrysanthi Skevaki,Jaclyn A. Smith,Ben Ainsworth,Mark H. Almond,Evangelos Andreakos,Maria G. Belvisi,Kian Fan Chung,William O.C.M. Cookson,Paul Cullinan,Catherine M. Hawrylowicz,Marek Lommatzsch,David A. Jackson,René Lutter,Benjamin J. Marsland,Miriam F. Moffatt,Mike Thomas,J. Christian Virchow,Georgina Xanthou,J. M. Edwards,Samantha Walker,Sebastian L. Johnston +23 more
TL;DR: This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes and describes a state-of-the-art view of the mechanisms involved in asthma onset, asthma progression and asthma exacerbations.
Journal ArticleDOI
Identification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium
James D. Porter,Jennifer Watson,Lee R. Roberts,Simren K. Gill,Helen T. Groves,Jaideep Dhariwal,Mark H. Almond,Ernie Wong,Ross P. Walton,Lyn H. Jones,John S. Tregoning,Iain Kilty,Sebastian L. Johnston,Michael R. Edwards +13 more
TL;DR: Evidence is provided that macrolides can be developed with anti-inflammatory, antibacterial and antiviral activity and show surprising versatility depending on the clinical need and the idea that macrology have antiviral properties through a mechanism that is yet to be ascertained is supported.
Journal ArticleDOI
Epitope-specific airway-resident CD4+ T cell dynamics during experimental human RSV infection.
Aleks Guvenel,Agnieszka Jozwik,Stephanie Ascough,Seng Kuong Ung,Suzanna Paterson,Mohini Kalyan,Zoe Gardener,Emma Bergstrom,Satwik Kar,Maximillian S. Habibi,Allan Paras,Jie Zhu,Mirae Park,Jaideep Dhariwal,Mark H. Almond,Ernie Wong,Annemarie Sykes,Jerico Del Rosario,Maria-Belen Trujillo-Torralbo,Patrick Mallia,John Sidney,Bjoern Peters,Onn Min Kon,Alessandro Sette,Alessandro Sette,Sebastian L. Johnston,Peter J. M. Openshaw,Christopher Chiu +27 more
TL;DR: Human infection challenge provides a unique opportunity to study the breadth of specificity and dynamics of RSV-specific T-cell responses in the target organ, allowing the precise investigation of Trm recognizing novel viral antigens over time.