C
Christopher D. Lascola
Researcher at Duke University
Publications - 65
Citations - 2885
Christopher D. Lascola is an academic researcher from Duke University. The author has contributed to research in topics: Intracerebral hemorrhage & Medicine. The author has an hindex of 20, co-authored 57 publications receiving 2315 citations. Previous affiliations of Christopher D. Lascola include Harvard University & University of Illinois at Chicago.
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Journal ArticleDOI
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction
João Peça,Catia Feliciano,Jonathan T. Ting,Wenting Wang,Michael F. Wells,Talaignair N. Venkatraman,Christopher D. Lascola,Zhanyan Fu,Zhanyan Fu,Guoping Feng,Guoping Feng,Guoping Feng +11 more
TL;DR: In this paper, Shank3 gene deletions were found to lead to repetitive grooming and impaired social interaction in mice with autism spectrum disorders (ASDs) and other non-syndromic ASDs.
Journal ArticleDOI
Modulation of Murine Breast Tumor Vascularity, Hypoxia, and Chemotherapeutic Response by Exercise
Allison S. Betof,Christopher D. Lascola,Douglas H. Weitzel,Chelsea D. Landon,Peter M. Scarbrough,Gayathri R. Devi,Gregory M. Palmer,Lee W. Jones,Mark W. Dewhirst +8 more
TL;DR: Exercise statistically significantly reduced tumor growth and was associated with a 1.4-fold increase in apoptosis in mice randomly assigned to exercise or sedentary control; exercise plus chemotherapy prolonged growth delay compared with chemotherapy alone (P < .001) in the orthotopic 4T1 model.
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction
João Peça,Catia Feliciano,Jonathan T. Ting,Wenting Wang,Michael F. Wells,Talaignair N. Venkatraman,Christopher D. Lascola,Zhanyan Fu,Zhanyan Fu,Guoping Feng,Guoping Feng,Guoping Feng +11 more
TL;DR: It is shown that mice with Shank3 gene deletions exhibit self-injurious repetitive grooming and deficits in social interaction and a critical role for SHANK3 in the normal development of neuronal connectivity is demonstrated.
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Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer.
George Philips,Isaac S. Chan,Isaac S. Chan,Marzena Swiderska,Vanessa T. Schroder,Cynthia D. Guy,Gamze Karaca,Cynthia A. Moylan,Talaignair N. Venkatraman,Sebastian Feuerlein,Wing-Kin Syn,Youngmi Jung,Youngmi Jung,Rafal P. Witek,Steve S. Choi,Gregory A. Michelotti,Fatima A. Rangwala,Elmar M. Merkle,Christopher D. Lascola,Anna Mae Diehl +19 more
TL;DR: Investigating the hypothesis that activation of the hedgehog (Hh) signaling pathway promotes development of both liver fibrosis and hepatocarcinogenesis in mice found that Mdr2−/− mice consistently expressed Hh ligands and progressively accumulated Hh-responsive liver myofibroblasts and progenitors with age.
Journal ArticleDOI
Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer
Lee W. Jones,Jodi Antonelli,Elizabeth M. Masko,Gloria Broadwater,Christopher D. Lascola,Diane Renee Fels,Mark W. Dewhirst,Jason R.B. Dyck,Jeevan Nagendran,Catherine Flores,Allison S. Betof,Erik R. Nelson,Michael Pollak,Rajesh C. Dash,Martin E. Young,Stephen J. Freedland +15 more
TL;DR: Exercise-induced stabilization of HIF-1α and subsequent upregulation of VEGF was associated with "productive" tumor vascularization with a shift toward suppressed metastasis in an orthotopic model of prostate cancer.