C
Christopher M. Overall
Researcher at University of British Columbia
Publications - 314
Citations - 31412
Christopher M. Overall is an academic researcher from University of British Columbia. The author has contributed to research in topics: Matrix metalloproteinase & Proteases. The author has an hindex of 90, co-authored 302 publications receiving 28860 citations. Previous affiliations of Christopher M. Overall include University of Toronto & Canadian Institutes of Health Research.
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Journal ArticleDOI
Metalloprotease Meprin β Generates Nontoxic N-terminal Amyloid Precursor Protein Fragments in Vivo
Tamara Jefferson,Mirsada Causevic,Ulrich auf dem Keller,Oliver Schilling,Simone Isbert,Rebecca Geyer,Wladislaw Maier,Sabrina Tschickardt,Thorsten Jumpertz,Sascha Weggen,Judith S. Bond,Christopher M. Overall,Claus U. Pietrzik,Christoph Becker-Pauly +13 more
TL;DR: It is demonstrated that meprin β is a physiologically relevant enzyme in APP processing, and n-terminal APP fragments were in the range of those responsible for caspase-induced neurodegeneration, and cytotoxicity to primary neurons treated by these fragments was not detected.
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Systems-Level Analysis of Proteolytic Events in Increased Vascular Permeability and Complement Activation in Skin Inflammation
TL;DR: The systems-level analysis of proteolysis dissected cleavage events associated with skin inflammation and demonstrated that loss of a single protease could perturb the proteolytic signaling network and enhance inflammation.
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Assessment of a novel screening test for neutrophil collagenase activity in the diagnosis of periodontal diseases.
Sabrina Mancini,Raquel Romanelli,Carol Laschinger,Christopher M. Overall,Jaro Sodek,Christopher A. McCulloch +5 more
TL;DR: Results indicate that active MMP-8 is detected in GCF by a novel assay that is specific, simple, rapid, and reproducible and which may facilitate diagnostic discrimination between stable and progressive lesions.
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Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome.
TL;DR: A new stabilizing N-end rule for processed protein termini is described, which discriminates novel protein species from degradation remnants, and identified protein domain hot spots susceptible to cleavage.
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A Novel Organ Culture Method to Study the Function of Human Odontoblasts in vitro: Gelatinase Expression by Odontoblasts is Differentially Regulated by TGF-β1
TL;DR: An organ culture method for human odonto-blasts that utilizes the pulp chamber as a culture crucible is presented and it is suggested that odontoblasts can be cultured even in serum-free conditions.