C
Christopher T. Walsh
Researcher at Stanford University
Publications - 841
Citations - 79830
Christopher T. Walsh is an academic researcher from Stanford University. The author has contributed to research in topics: Nonribosomal peptide & Active site. The author has an hindex of 139, co-authored 819 publications receiving 74314 citations. Previous affiliations of Christopher T. Walsh include Florida State University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Fluorinated substrate analogues as stereochemical probes of enzymatic reaction mechanisms.
Journal ArticleDOI
Determination of the Absolute Number of Escherichia coli Membrane Vesicles That Catalyze Active Transport
S. A. Short,H R Kaback,Gregory J. Kaczorowski,Jed F. Fisher,Christopher T. Walsh,S. C. Silverstein +5 more
TL;DR: The experiments provide a strong indication that most, if not all, of the membrane vesicles in these preparations catalyze active transport and are likely to be labeled with vinylglycolate.
Journal ArticleDOI
Kinetic analysis of three activated phenylalanyl intermediates generated by the initiation module PheATE of gramicidin S synthetase.
Lusong Luo,Christopher T. Walsh +1 more
TL;DR: This study provides the first transient-state kinetic analysis of a nonribosomal peptide synthetase (NRPS) module by examining PheATE in single-turnover catalysis using rapid chemical quench techniques.
Journal ArticleDOI
Construction of a synthetic gene for the metalloregulatory protein MerR and analysis of regionally mutated proteins for transcriptional regulation.
TL;DR: The construction and utilization of a synthetic merR gene and a single-copy merT'-lacZ fusion reporter are used for mutagenic analysis of the MerR protein's function and a unique disulfide bond bridging this CA mutant's dimer interface is proposed to constrain protein conformation in a manner analogous to mercuric ion binding in the wild-type protein.