C
Christopher T. Walsh
Researcher at Stanford University
Publications - 841
Citations - 79830
Christopher T. Walsh is an academic researcher from Stanford University. The author has contributed to research in topics: Nonribosomal peptide & Active site. The author has an hindex of 139, co-authored 819 publications receiving 74314 citations. Previous affiliations of Christopher T. Walsh include Florida State University & Massachusetts Institute of Technology.
Papers
More filters
Journal ArticleDOI
Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis.
TL;DR: The aminocoumarin antibiotics clorobiocin and coumermycin A(1) target the B subunit of DNA gyrase by presentation of the 5-methyl-pyrrolyl-2-carboxy ester moiety in the ATP-binding site of the enzyme.
Journal ArticleDOI
In vitro and in vivo functional characterization of bovine vitamin K-dependent gamma-carboxylase expressed in Chinese hamster ovary cells.
Alnawaz Rehemtulla,David M. Roth,Louise C. Wasley,Athan Kuliopulos,Christopher T. Walsh,Bruce Furie,Barbara C. Furie,Randal J. Kaufman +7 more
TL;DR: The results demonstrate that the ability of CHO cells to modify glutamic acid residues to gamma-carboxyglutamic acid in secreted factor IX is not limited by the expression of the vitamin K-dependent gamma- carboxylase alone.
Journal ArticleDOI
Enzymatic Processing of Fumiquinazoline F: A Tandem Oxidative-Acylation Strategy for the Generation of Multicyclic Scaffolds in Fungal Indole Alkaloid Biosynthesis
TL;DR: Experimental validation of the fumiquinazoline biosynthetic cluster of A. fumigatus Af293 is provided and an oxidative annulation biosynthesis strategy likely shared among several classes of polycyclic fungal alkaloids is described.
Journal ArticleDOI
Characterization of vanY, a DD-carboxypeptidase from vancomycin-resistant Enterococcus faecium BM4147.
TL;DR: It is demonstrated that VanY should contribute in vivo to the hydrolysis of both the D-alanyl-D-alanine- and the depsipeptide-containing peptidoglycan precursors.