C
Christopher T. Walsh
Researcher at Stanford University
Publications - 841
Citations - 79830
Christopher T. Walsh is an academic researcher from Stanford University. The author has contributed to research in topics: Nonribosomal peptide & Active site. The author has an hindex of 139, co-authored 819 publications receiving 74314 citations. Previous affiliations of Christopher T. Walsh include Florida State University & Massachusetts Institute of Technology.
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Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol.
TL;DR: The first biochemical characterization of an enzyme involved in the biosynthesis of chloramphenicol is reported that provides new insights into the origins of the antibiotic.
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Allylic and propargylic phenyl selenide oxygenation by cyclohexanone oxygenase: [2,3]-sigmatraopic rearrangement of the enzyme-generated selenoxide
TL;DR: Enzymic oxidation of propargyloic and allylic selenides has been carried out and the resulting selenoxides found to readily undergo 2,3-sigmatropic rearrangement.
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Kinetic Characterization of the Inactivation of UDP-GlcNAc Enolpyruvyl Transferase by (Z)-3-Fluorophosphoenolpyruvate: Evidence for Two Oxocarbenium Ion Intermediates in Enolpyruvyl Transfer Catalysis
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Synthesis of proposed oxidation-cyclization-methylation intermediates of the coumarin antibiotic biosynthetic pathway.
TL;DR: A chemoenzymatic synthesis was described to prepare proposed oxidation-cyclization-methylation intermediates of the coumarin antibiotic biosynthetic pathway to minimize epimerization, decomposition, multiple orthogonal protections, and retro aldol reactions often encountered in their chemical synthesis.
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A double TROSY hNCAnH experiment for efficient assignment of large and challenging proteins
TL;DR: An experiment that allows for a straightforward assignment of NMR resonances, even in large and/or challenging proteins, is presented and resolves ambiguities occurring in traditional methods which involve time-consuming and cumbersome strip comparisons obtained with series of triple-resonance spectra.