C
Christopher T. Walsh
Researcher at Stanford University
Publications - 841
Citations - 79830
Christopher T. Walsh is an academic researcher from Stanford University. The author has contributed to research in topics: Nonribosomal peptide & Active site. The author has an hindex of 139, co-authored 819 publications receiving 74314 citations. Previous affiliations of Christopher T. Walsh include Florida State University & Massachusetts Institute of Technology.
Papers
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Journal ArticleDOI
Lessons from natural molecules
Jon Clardy,Christopher T. Walsh +1 more
TL;DR: Improvements in approaches for natural-product isolation, characterization and synthesis could be opening the door to a new era in the investigation of natural products in academia and industry.
Book
Antibiotics: Actions, Origins, Resistance
TL;DR: This new text offers a comprehensive, up to date account of those structural classes of antibiotics that have had an impact in human infectious disease.
Journal ArticleDOI
A new enzyme superfamily — the phosphopantetheinyl transferases
Ralph H. Lambalot,Amy M. Gehring,Roger S. Flugel,Peter Zuber,Michael LaCelle,Mohamed A. Marahiel,Ralph Reid,Chaitan Khosla,Christopher T. Walsh +8 more
TL;DR: This work has identified a large family of proteins having 12-22 % similarity with ACPS, which are putative P-pant transferases, and found three of these proteins, E. coli EntD and o195, and subtilis Sfp, have been overproduced, purified and found to have P- pant transferase activity.
Journal ArticleDOI
Non-heme Fe(IV)-oxo intermediates.
TL;DR: The observation of non-heme Fe(IV)-oxo intermediates and Fe(II)-containing product(s) complexes with almost identical spectroscopic parameters in the reactions of two distantly related alphaKG-dependent hydroxylases suggests that members of this subfamily follow a conserved mechanism for substrate hydroxyation.