C
Christopher T. Walsh
Researcher at Stanford University
Publications - 841
Citations - 79830
Christopher T. Walsh is an academic researcher from Stanford University. The author has contributed to research in topics: Nonribosomal peptide & Active site. The author has an hindex of 139, co-authored 819 publications receiving 74314 citations. Previous affiliations of Christopher T. Walsh include Florida State University & Massachusetts Institute of Technology.
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Prospects for new antibiotics: a molecule-centered perspective
TL;DR: This work brings a molecule-centered perspective to the questions of where will new scaffolds come from, when will chemogenetic approaches yield useful new antibiotics and what existing bacterial targets merit contemporary re-examination.
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Aminoacyl-CoAs as Probes of Condensation Domain Selectivity in Nonribosomal Peptide Synthesis
TL;DR: This method was used to demonstrate that the first condensation domain of tyrocidine synthetase shows low selectivity at the donor residue (D-phenylalanine) and higher selectivity in the formation of the chain-initiating D-Phe-L-Pro dipeptidyl-enzyme intermediate.
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An alternative 7-ethoxyresorufin o-deethylase activity assay: A continuous visible spectrophotometric method for measurement of cytochrome P-450 monooxygenase activity
TL;DR: The application of this enzyme assay in a visible spectrophotometer, along with the considerable evidence that a single aromatic hydrocarbon-inducible cytochrome P-450 isozyme is responsible for the catalysis, enhances the utility of this substrate in microsomal monooxygenase assays.
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Crystal structure of the non-haem iron halogenase SyrB2 in syringomycin biosynthesis.
Leah C. Blasiak,Frédéric H. Vaillancourt,Frédéric H. Vaillancourt,Christopher T. Walsh,Catherine L. Drennan +4 more
TL;DR: The structure of SyrB2 is reported with both a chloride ion and αKG coordinated to the iron ion at 1.6 Å resolution, revealing a previously unknown coordination of iron, in which the carboxylate ligand of the facial triad is replaced by a chloride ions.
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The Genetic and Molecular Basis for Sunscreen Biosynthesis in Cyanobacteria
TL;DR: The identification of a MAA biosynthetic gene cluster in a cyanobacterium and the discovery of analogous pathways in other sequenced organisms are reported.